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REGISTRY OF ACUTE CEREBRAL CIRCULATORY DISORDERS LIS-2: NEW DATA ON LONG-TERM FOLLOW-UP

https://doi.org/10.20996/1819-6446-2018-14-2-260-265

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Abstract

Aim. To assess long-term outcomes in patients after acute stroke within LIS-2 registry.

Material and methods. 960 patients hospitalized in 2009-2011 due to acute stroke in one of the district hospitals of Lyubertsy town were included into analysis. The first assessment of the life status was carried out in 2012-2013 through 2.8 [2.1; 3.5] years after discharge, and a reassessment was in 2017 through 7-8 years after discharge, median follow-up 6.1 [6.9; 7.7] years. The primary endpoint was total mortality. Survival was assessed using the Kaplan-Meier curves.

Results. Only 300 patients were alive by the end of the follow-up, 543 patients died, and life status of 117 patients were unknown. Kaplan-Mayer curves showed that mortality was the highest during the first year after stroke, and then it stabilized and remained unchanged till the end of the followup. Less than a third of patients were alive after 8 years of follow-up. The identification of causes of death was difficult in a significant number of cases (in 52% of cases the cause was unknown). Acute stroke and other cerebrovascular diseases, as causes of death, were found in 15% of deaths, other cardiovascular diseases – in 18%, oncological diseases – in 7%, injuries – in 4%. Such causes of death as acute myocardial infarction, pulmonary disease or pulmonary embolism accounted for only 2% in the structure of deaths. A trend towards decrease in the proportion of recurrent stroke as the cause of death was observed as the follow-up period increases.

Conclusion. Mortality rate of patients after acute stroke remains stably high throughout the follow-up period: after 8 years less than a third of patients were alive. Death from acute stroke and cardiovascular diseases prevailed among the main causes of death at a distant stage of observation. It is necessary to analyze the factors determining the long-term outcomes at different periods after the stroke.

About the Authors

S. Yu. Martsevich
National Medical Research Center for Preventive Medicine
Russian Federation

Sergey Yu. Martsevich – MD, PhD, Professor, Head of Department of Preventive Pharmacotherapy

Petroverigsky per. 10, Moscow, 101990



N. P. Kutishenko
National Medical Research Center for Preventive Medicine
Russian Federation

Natalia P. Kutishenko – MD, PhD, Head of Laboratory of Pharmacoeconomic Studies, Department of Preventive Pharmacotherapy

Petroverigsky per. 10, Moscow, 101990



A. V. Zagrebelnyy
National Medical Research Center for Preventive Medicine
Russian Federation

Alexander V. Zagrebelnyy – MD, PhD, Senior Researcher, Department of Preventive Pharmacotherapy

Petroverigsky per. 10, Moscow, 101990



Yu. V. Lukina
National Medical Research Center for Preventive Medicine
Russian Federation

Yulia V. Lukina – MD, PhD, Leading Researcher, Department of Preventive Pharmacotherapy

Petroverigsky per. 10, Moscow, 101990



М. L. Ginzburg
Lyubertsy District Hospital №2
Russian Federation

Moisey L. Ginzburg – MD, PhD, Head of Cardiology Department

Oktyabrskiy prospect, 338, Lyubertsy, 140006



A. V. Fokina
Lyubertsy District Hospital №2
Russian Federation

Anna V. Fokina – MD, Doctor of Cardiology Department

Oktyabrskiy prospect, 338, Lyubertsy, 140006



E. V. Daniels
Lyubertsy District Hospital №2
Russian Federation

Elena V. Daniels – MD, Doctor of Cardiology Department

Oktyabrskiy prospect, 338, Lyubertsy, 140006



A. D. Deev
National Medical Research Center for Preventive Medicine
Russian Federation

Alexander D. Deev – PhD (Physics and Mathematics), Head of Laboratory of Biostatistics, Department of Epidemiology of Chronic Non-Communicable Diseases

Petroverigsky per. 10, Moscow, 101990



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For citation:


Martsevich S.Y., Kutishenko N.P., Zagrebelnyy A.V., Lukina Y.V., Ginzburg М.L., Fokina A.V., Daniels E.V., Deev A.D. REGISTRY OF ACUTE CEREBRAL CIRCULATORY DISORDERS LIS-2: NEW DATA ON LONG-TERM FOLLOW-UP. Rational Pharmacotherapy in Cardiology. 2018;14(2):260-265. (In Russ.) https://doi.org/10.20996/1819-6446-2018-14-2-260-265

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ISSN 1819-6446 (Print)
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