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PILOT STUDY RESULTS OF THE INFLUENCE OF CITICOLINE AND PIRIBEDIL ON COGNITIVE FUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE AFTER CORONARY ARTERY BYPASS SURGERY

https://doi.org/10.20996/1819-6446-2015-11-4-391-397

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Abstract

Aim. To reveal cognitive deficit after coronary artery bypass, the influence of citicoline, piribedil on the state of higher cerebral functions in the early and late periods after surgery.

Material and methods. The study included 94 patients with ischemic heart disease. All patients were divided into 3 groups. Patients of the first group (n=30) were prescribed citicoline as a cerebral neuroprotective drug. Patients of the second group (n=32) had piribedil in addition to standard therapy. Patients of the control group (n=32) had only a standard treatment without any neuroprotective drugs. All patients underwent coronary artery bypass surgery. The cognitive function was assessed before, 10 days after and six months after coronary artery bypass.

Results. Patients of group 1 and 2 had achieved pre-surgical levels of cognitive tests results 6 months after coronary artery bypass. The control group had achieved initial levels only in three tests: visual memory (immediate simulation; p=0.008), categorical association (p=0.002), clock drawing test (Wilcoxon test; p=0,005), while other indices were reduced in comparison with the initial ones.

Conclusion. The obtained results allow considering the studied drugs as a protectors of cognitive function after surgery. Randomized controlled double-blind studies on large samples are needed to confirm these results.

About the Authors

M. M. Petrova
Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky
Russian Federation
Partizana Zheleznjaka ul. 1, Krasnoyarsk, 660022 Russia


S. V. Prokopenko
Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky
Russian Federation
Partizana Zheleznjaka ul. 1, Krasnoyarsk, 660022 Russia


O. V. Eremina
Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky
Russian Federation
Partizana Zheleznjaka ul. 1, Krasnoyarsk, 660022 Russia


G. V. Matjushin
Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky
Russian Federation
Partizana Zheleznjaka ul. 1, Krasnoyarsk, 660022 Russia


V. A. Sakovich
Federal Center of Cardiovascular Surgery
Russian Federation
Karaul’naya ul. 45, Krasnoyarsk, 660022 Russia


D. B. Drobot
Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Federal Center of Cardiovascular Surgery
Russian Federation

Partizana Zheleznjaka ul. 1, Krasnoyarsk, 660022 Russia

Karaul’naya ul. 45, Krasnoyarsk, 660022 Russia



E. Yu. Mozhejko
Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky
Russian Federation
Partizana Zheleznjaka ul. 1, Krasnoyarsk, 660022 Russia


D. S. Kaskaeva
Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky
Russian Federation
Partizana Zheleznjaka ul. 1, Krasnoyarsk, 660022 Russia


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For citation:


Petrova M.M., Prokopenko S.V., Eremina O.V., Matjushin G.V., Sakovich V.A., Drobot D.B., Mozhejko E.Y., Kaskaeva D.S. PILOT STUDY RESULTS OF THE INFLUENCE OF CITICOLINE AND PIRIBEDIL ON COGNITIVE FUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE AFTER CORONARY ARTERY BYPASS SURGERY. Rational Pharmacotherapy in Cardiology. 2015;11(4):391-397. (In Russ.) https://doi.org/10.20996/1819-6446-2015-11-4-391-397

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ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)