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Rational Pharmacotherapy in Cardiology

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COMORBID PATIENT IN GASTROENTEROLOGY: INDIVIDUAL APPROACH

https://doi.org/10.20996/1819-6446-2018-14-1-65-69

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Abstract

In connection with the increase in the life expectancy of modern people, in recent years questions of comorbid conditions have become of great interest among clinicians. Comorbidity, which increases with the age of patients, may reduce their adherence to treatment, including because of the use of multicomponent regimens of therapy, which in turn leads to a decrease in the effectiveness of the treatment. In this regard, there is a need for individual adjustment of therapeutic regimens with minimal drug interactions. In the article, a clinical case is presented as a therapeutic and diagnostic algorithm for a comorbid patient with combination of the digestive and cardiovascular systems disorders. The choice of therapeutic-diagnostic algorithm was based on modern Russian and foreign recommendations. The emphasis is on the stratification of both gastroenterological and cardiologic risk factors, and the strategy for choosing proton pump inhibitors, depending on clinical dynamics. The rationale for the replacement of proton pump inhibitors is given, taking into account the probability of inter-drug interactions in a patient with high cardiovascular risk taking acetylsalicylic acid and having a high risk of gastrointestinal tract bleeding. The data of several large meta-analyzes reflecting approaches to reduce the risk of gastropathy associated with non-steroidal anti-inflammatory drugs due to the use of disaggregants as well as eradication therapy in these patients are presented.

About the Authors

I. G. Bakulin
North-Western State Medical University named after I.I. Mechnikov
Russian Federation

Igor G. Bakulin – MD, PhD, Professor, Head of Chair of Propaedeutics of Internal Diseases, Gastroenterology and Dietetics 

Kirochnaya ul. 41, St. Petersburg, 191015



S. A. Sayganov
North-Western State Medical University named after I.I. Mechnikov
Russian Federation

Sergey A. Sayganov – MD, PhD, Professor, Head of Chair of Hospital Therapy and Cardiology named after M.S. Kushakovsky 

Kirochnaya ul. 41, St. Petersburg, 191015



M. I. Skalinskaya
North-Western State Medical University named after I.I. Mechnikov
Russian Federation

Maria I. Skalinskaya – MD, PhD, Associate Professor, Chair of Propaedeutics of Internal Diseases, Gastroenterology and Dietetics 

Kirochnaya ul. 41, St. Petersburg, 191015



E. V. Skazyayeva
North-Western State Medical University named after I.I. Mechnikov
Russian Federation

Ekaterina V. Skazyayeva – MD, PhD, Associate Professor, Chair of Propaedeutics of Internal Diseases, Gastroenterology and Dietetics 

Kirochnaya ul. 41, St. Petersburg, 191015



I. V. Lapinskii
North-Western State Medical University named after I.I. Mechnikov
Russian Federation

Igor V. Lapinskii – MD, Assistant, Chair of Propaedeutics of Internal Diseases, Gastroenterology and Dietetics 

Kirochnaya ul. 41, St. Petersburg, 191015



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For citation:


Bakulin I.G., Sayganov S.A., Skalinskaya M.I., Skazyayeva E.V., Lapinskii I.V. COMORBID PATIENT IN GASTROENTEROLOGY: INDIVIDUAL APPROACH. Rational Pharmacotherapy in Cardiology. 2018;14(1):65-69. (In Russ.) https://doi.org/10.20996/1819-6446-2018-14-1-65-69

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ISSN 1819-6446 (Print)
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