Rational Pharmacotherapy in Cardiology

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Aim. To study serum level of leptin in patients with the metabolic syndrome (MS), including in patients with MS in combination with left ventricular hypertrophy (LVH) to determine the diagnostic significance of this marker in MS.

Material and methods. The study involved 43 patients with MS, 33 of them with signs of LVH, and 33 patients without MS comparable age, including 10 patients with LVH. The average age of patients in the MS group at the time of inclusion into the study was 62.7±10.3 years, in the control group (without MS) – 60±14.7 years. All patients underwent a comprehensive examination that included the collection of complaints, study of history, physical examination, anthropometric measurements, laboratory and instrumental examination, including study of the serum level of leptin.

Results. Patients of both groups had statistically significant differences in the size of the heart chambers, the presence of LVH signs, left ventricle contractile function, the thickness of the epicardial fat layer. Thus, enlargement of the heart, thickness of the interventricular septum, posterior wall of the left ventricle, thickness of epicardial fat, reduction of ejection fraction of the left ventricle and characteristics of aortic atherosclerosis were observed significantly more often in patients with MS compared with the group without MS (p<0.05).The average serum level of leptin in the MS group (41.89±33.28 ng/ml) was significantly higher compared to the group without MS (17.64±16.87 ng/ml), p<0.001. At that women had significantly higher levels of serum leptin (38.65±29.23 ng/ml) compared to males (19.54±27.23 ng/ml), p=0.006. A positive correlation between leptin levels and symptoms of LVH (r=0.294, p<0.001) was revealed: in the absence of LVH average level of leptin was 21.7±4.1 ng/ml, in the presence of signs of LVH – 39.2±4.95 ng/ml.

Conclusions. Leptin levels in MS patients is higher than in patients without MS, and in patients with MS associated with LVH is higher than in MS patients without LVH. As the leptin level increases, the risk of LVH increases.

About the Authors

O. M. Drapkina
National Medical Research Center for Preventive Medicine
Russian Federation

Oksana M. Drapkina – MD, PhD, Professor, Corresponding Member of the Russian Academy of Sciences, Director 

Petroverigsky per. 103, Moscow, 101990

R. N. Shepel
National Medical Research Center for Preventive Medicine
Russian Federation

 Ruslan N. Shepel – MD, Junior Researcher, Department of Fundamental and Applied Aspects of Obesity

Petroverigsky per. 103, Moscow, 101990

T. A. Deeva
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Tatyana A. Deeva – MD, Postgraduate Student, Chair of Internal Medicine Propaedeutics

Trubetskaya ul. 8, Moscow, 119991


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