Preview

Rational Pharmacotherapy in Cardiology

Advanced search

ARTERIAL HYPERTENSION IN THE PRESENCE OF OVERWEIGHT AND OBESITY. THE CAPABILITIES OF AMLODIPINE AND LISINOPRIL COMBINATION. Part 2. Antihypertensive and Organoprotective Effects of Amlodipine/Lisinopril Fixed-Dose Combination in Patients with Arterial Hypertension in the Presence of Overweight and Obesity

https://doi.org/10.20996/1819-6446-2017-13-6-841-850

Full Text:

Abstract

Advantages of amlodipine, lisinopril and their fixed-dose combination are presented regarding to antihypertensive effect and target-organs protection in patients with arterial hypertension in the presence of obesity. Abnormalities in myocardial strain, increased stiffness of the left heart chambers, left ventricular hypertrophy are considered as "new" risk factors in hypertensive patients along with disturbances in some parameters of blood pressure and its daily profile. Current data about various pathophysiological mechanisms of the favorable impact of calcium channel blockers, as well as angiotensin-converting enzyme inhibitors, are described, in particular, lisinopril-mediated beneficial effects on myocardial stiffness and regression of myocardial hypertrophy.

About the Authors

O. D. Ostroumova
A.I. Evdokimov Moscow State University of Medicine and Dentistry; I.M. Sechenov First Moscow State Medical University
Russian Federation

Olga D. Ostroumova – MD, PhD, Professor, Chair of Faculty Therapy and Occupational Diseases, A.I. Evdokimov Moscow State University of Medicine and Dentistry; Chair of Clinical Pharmacology and Propaedeutics of Internal Diseases, I.M. Sechenov First Moscow State Medical University 

Trubetskaya ul. 8, Moscow, 119991



A. I. Kochetkov
A.I. Evdokimov Moscow State University of Medicine and Dentistry
Russian Federation

Alexey I. Kochetkov – MD, Assistant, Chair of Faculty Therapy and Occupational Diseases 

Delegatskaya ul. 20-1, Moscow, 127473



I. I. Kopchjonov
A.I. Evdokimov Moscow State University of Medicine and Dentistry
Russian Federation

Ivan I. Kopchjonov – MD, PhD, Associate Professor, Chair of Faculty Therapy and Occupational Diseases 

Delegatskaya ul. 20-1, Moscow, 127473



V. M. Fomina
A.I. Evdokimov Moscow State University of Medicine and Dentistry
Russian Federation

Vera M. Fomina – MD, PhD, Associate Professor, Chair of Faculty Therapy and Occupational Diseases 

Delegatskaya ul. 20-1, Moscow, 127473



References

1. Boytsov S.A., Deev A.D., Shalnova S.A. Mortality and risk factors for non-communicable diseases in Russia: Specific features, trends, and prognosis. Ter Arkhiv. 2017;89(1):5-13. (In Russ.) [Бойцов С.А., Деев А.Д., Шальнова С.А. Смертность и факторы риска неинфекционных заболеваний в России: особенности, динамика, прогноз. Терапевтический Архив. 2017;89(1):5-13]. doi: 10.17116/terarkh20178915-13.

2. Samorodskaja I.V., Bolotova E.Y., Boytsov S.A. Paradox of obesity and cardiovascular mortality. Kardiologiia. 2015;55(9):31-6. (In Russ.) [Самородская И.В., Болотова Е.В., Бойцов С.А. Парадокс ожирения и сердечно-сосудистая смертность. Кардиология. 2015;55(9):31-6]. doi: 10.18565/cardio.2015.9.31-36.

3. Chazova I.E., Ratova L.G., Boitsov S.A., Nebieridze D.V. Guidelines for the management of arterial hypertension Russian Medical Society of Arterial Hypertension and Society of Cardiology of the Russian Federation. Sistemnye Gipertenzii. 2010;3:5-26. (In Russ.) [Чазова И.Е., Ратова Л.Г., Бойцов С.А., Небиеридзе Д.В. Диагностика и лечение артериальной гипертензии (Рекомендации Российского медицинского общества по артериальной гипертонии и Всероссийского научного общества кардиологов). Системные гипертензии 2010;3:5-26].

4. Mancia G., Fagard R., Narkiewicz K., et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2013;31:1281357. doi: 10.1097/01.hjh.0000431740.32696.cc.

5. Jamerson K., Weber M. A., Bakris G. L., et al. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. New England Journal of Medicine. 2008;359(23):2417-28. doi: 10.1056/NEJMoa0806182.

6. Donskaja A.A., Morozov S.N., Morozova E.A. Evaluation of the effect of monotherapy with the Equator on hemodynamic parameters in persons with arterial hypertension. Cardiovascular Therapy and Prevention. 2008;6(4) Suppl 2:37. (In Russ.) [ДонскаяА.А. Морозов С.Н., Морозова Е.А. Оценка влияния монотерапии Экватором на гемодинамические показатели у лиц с артериальной гипертонией. Кардиоваскулярная Терапия и Профилактика. 2008;6(4) Приложение 2:37].

7. Ersh I.R. Zaicev V.I., Romanchuk E.V., et al. Efficacy of long-term therapy with the Equator in patients with arterial hypertension in ambulatory conditions. Mezhdunarodnye Obzory: Klinicheskaya Praktika i Zdorov’e. 2014;2(8):74-86. (In Russ.) (Ерш И.Р., Зайцев В.И., Романчук Э.В., и др. Эффективность длительной терапии препаратом Экватор больных артериальной гипертензией в амбулаторных условиях. Международные Обзоры: Клиническая Практика и Здоровье. 2014;2(8):74-86].

8. Kozhyrenko A.V. Clinical and epidemiological characteristics of arterial hypertension in young and middle-aged men in organized groups. The author's abstract of the dissertation of the candidate of medical sciences 2009. (In Russ.) (Козыренко А. В. Клинико-эпидемиологическая характеристика артериальной гипертонии у мужчин молодого и среднего возраста в организованных коллективах. Автореф. дисс. канд. мед. наук 2009).

9. Ostroumova O.D., Kochetkov A.I., Lopukhina M.V. Comparative analysis of the efficacy of fixed-dose combinations of amlodipine/Lisinopril and bisoprolol/hydrochlorthiazide in patients with essential arterial hypertension combined with obesity and overweight. Rational Pharmacotherapy in Cardiology. 2017;13(4):457-67. (In Russ.) [Остроумова О.Д., Кочетков А.И., Лопухина М.В. Сравнительный анализ эффективности фиксированных комбинаций амлодипин/лизиноприл и бисопролол/гидрохлоротиазид у пациентов с гипертонической болезнью в сочетании с ожирением и избыточной массой тела. Рациональная Фармакотерапия в Кардиологии. 2017;13(4):443-53.] doi: 10.20996/1819-6446-2017-13-4-443-453.

10. Nedogoda S.V., Chumachek E.V., Ledyaeva A.A., et al. Comparative effectiveness of fixed-dose combinations of lisinopril/amlodipine and enalapril/hydrochlorothiazide. Cardiovascular Therapy and Prevention. 2013;12(2):25-29. (In Russ.) [Недогода С. В., Чумачек Е. В., Ледяева А. А., и др. Сравнительная эффективность фиксированных комбинаций лизиноприла с амлодипином и эналаприла с гидрохлортиазидом. Кардиоваскулярная Терапия и Профилактика. 2013;12(2):25-9]. doi: 10.15829/1728-8800-2013-2-25-29.

11. Multiple Risk Factor Intervention Trial Research Group. Relationship between baseline risk factors and coronary heart disease and total mortality in the Multiple Risk Factor Intervention Trial. Prev Med. 1986;15:254-73. doi: 10.1016/0091-7435(86)90045-9.

12. Kannel W. Risk stratification in hypertension: new insights from the Framingham Study. Am J Hyper. 2000;13(Pt. 2):S3−S10. doi: 10.1016/S0895-7061(99)00252-6.

13. Dahlöf B., Sever P.S., Poulter N.R., et al.; ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT-BPLA): a multicentre randomized controlled trial. Lancet. 2005;366:895-906. doi: 10.1016/S01406736(05)67185-1.

14. Williams B., Lacy P.S., Thom S.M., et al.; CAFE Investigators; Anglo-Scandinavian Cardiac Outcomes Trial Investigators; CAFE Steering Committee and Writing Committee. Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation 2006;113(9):1213-25. doi: 10.1161/CIRCULATIONAHA.105.595496.

15. Domanski M.J., Davis B.R., Pfeffer M.A., et al. Isolated systolic hypertension: prognostic information provided by pulse pressure. Hypertension. 1999;34:375-380. doi: 10.1161/01.HYP.34.3.375.

16. Fernández-Escribano HernЗndez M., SuЗrez FernЗndez C., SЗez Vaquero T., et al. Relationship between pulse pressure and clinical cardiovascular damage in elderly subjects of EPICARDIAN study. Rev Clin Esp. 2007;207(6):284-290. doi: 10.1157/13106850.

17. Nair G.V., Chaput L.A., Vittinghoff E., Herrington D.M. Heart and Estrogen/Progestin Replacement Study Investigators. Pulse pressure and cardiovascular events in postmenopausal women with coronary heart disease. Chest. 2005;127(5):1498-506. doi: 10.1378/chest.127.5.1498.

18. Peters R., Beckett N., Fagard R., et al. Increased pulse pressure linked to dementia: further results from the Hypertension in the Very Elderly Trial HYVET. J Hypertens. 2013;31(9):1868-75. doi: 10.1097/HJH.0b013e3283622cc6.

19. Benetos A., Safar M., Rudnichi A., et l. Pulse pressure. Hypertension. 1997:30(6);1410-1415. doi: 10.1161/01.HYP.30.6.1410.

20. Dolan E., Stanton A.V., Thom S., et al.; ASCOT Investigators. Ambulatory blood pressure monitoring predicts cardiovascular events in treated hypertensive patients an Anglo-Scandinavian cardiac outcomes trial substudy. J Hypertens. 2009;27(4):876-885. doi: 10.1097/HJH.0b013e328322cd62.

21. Dolan E., Stanton A., Thijs L., et al. Superiority of ambulatory over clinic blood pressure measurement in predicting mortality: the Dublin outcome study. Hypertension. 2005;46:156-61. doi: 10.1161/01.HYP.0000170138.56903.7a.

22. Fagard R. H., Thijs L., Staessen J. A., et al. Night-day blood pressure ratio and dipping pattern as predictors of death and cardiovascular events in hypertension. J Hum Hypertens. 2009;23(10):64553. doi: 10.1038/jhh.2009.9.

23. Kario K., Pickering T.G., Matsuo T., et al. Stroke prognosis and abnormal nocturnal blood pressure falls in older hypertensives. Hypertension. 2001;38(4):852-7. doi: 10.1161/hy1001.092640.

24. London G., Schmieder R., Calvo C., Asmar R. Indapamide SR versus candesartan and amlodipine in hypertension: the X-CELLENT Study. American Journal of Hypertension. 2006;19(1):113-21. doi: 10.1016/j.amjhyper.2005.06.027.

25. Mancia G., Parati G., Bilo G., et al. Assessment of long-term antihypertensive treatment by clinic and ambulatory blood pressure: data from the European Lacidipine Study on Atherosclerosis. J Hypertens. 2007;25:1087-94. doi: 10.1097/HJH.0b013e32805bf8ce.

26. Ichihara A., Kaneshiro Y., Takemitsu T., Sakoda M. Effects of amlodipine and valsartan on vascular damage and ambulatory blood pressure in untreated hypertensive patients. J Hum Hypertens. 2006;20:787-94. doi: 10.1038/sj.jhh.1002067.

27. Verdecchia P., Angeli F., Gattobigio R., et al. Impact of blood pressure variability on cardiac and cerebrovascular complications in hypertension. American Journal of Hypertension. 2007;20(2):15461. doi: 10.1016/j.amjhyper.2006.07.017.

28. Kario K., Pickering T.G., Umeda Y., et al. Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives. A prospective study. Circulation. 2003;107:1401-6. doi: 10.1161/01.CIR.0000056521.67546.AA.

29. Schillaci G., Verdecchia P., Porcellati C., et al. Continuous relation between left ventricular mass and cardiovascular risk in essential hypertension. Hypertens. 2000;35:580-6. doi: 10.1161/01.HYP.35.2.580.

30. Nakili B., Okin P., Devereux R. Prognostic implications of left ventricular hypertrophy. Am Heart J. 2001;141:334-41. doi: 10.1067/mhj.2001.113218.

31. Schirmer H., Lunde P., Rasmussen K. Prevalence of left ventricular hypertrophy in a general population. The Tromso Study. Eur Heart J. 1999;20:429-38. doi: 10.1053/euhj.1998.1314.

32. Bakaev R., Strutynskij A., Glazunov A., et al. Equator in patients with hypertension, combined with coronary heart disease and chronic heart failure. Vrach. 2010;2:44-7. (In Russ.) [Бакаев Р., Струтынский А., Глазунов А., Каракин А., Воронина М., Пехтерева Д. Экватор у больных с гипертонической болезнью, сочетающейся с ишемической болезнью сердца и хронической сердечной недостаточностью. Врач. 2010;2:44-7].

33. Terpstra W.F., May J.F., Smit A.J., et al. Long-term effects of amlodipine and lisinopril on left ventricular mass and diastolic function in elderly, previously untreated hypertensive patients: the ELVERA trial. J Hypertens. 2001;19(2):303-9.

34. Soroka N.F., Bel'skaya E.S. Equator fixed-dose combination of amlodipine and lisinopril in the treatment of patients with arterial hypertension. Zdravookhranenie. 2007;7:17-21. (In Russ.) [Сорока Н.Ф., Бельская Е.С. Экватор фиксированная комбинация лизиноприла и амлодипина в лечении больных артериальной гипертензией. Здравоохранение. 2007;7:17-21].

35. Prokof'eva E.B., Glezer M.G. The stiffness of the arterial wall and the central hemodynamics with prolonged combined antihypertensive therapy. Kardiologiia. 2015;4(55):19-24. (In Russ.) [Прокофьева Е.Б., Глезер М.Г. Жесткость артериальной стенки и показатели центральной гемодинамики на фоне длительной комбинированной антигипертензивной терапии. Кардиология. 2015;4(55):19-24]. doi: 10.18565/cardio.2015.4.19-24.

36. Morozov S.N., Donskaja A.A., Morozova E.A. The effectiveness of the equator treatment of patients with arterial hypertension (evidence from Yakutsk). Yakutskij Medicinskij Zhurnal. 2008;4(24):9-12. (In Russ.) [Морозов С.Н., Донская А.А., Морозова Е.А. Эффективность терапии экватором больных с артериальной гипертонией (на примере г. Якутска). Якутский Медицинский Журнал. 2008;4(24):9-12].

37. Kakhramanova S.M., Bahshaliev A.B. Antihypertensive and cardioprotective efficacy of the Equator in patients with essential hypertension. “Russian National Congress of Cardiologists. Improving the quality and availability of cardiac care (Congress materials)”. Cardiovascular Therapy and Prevention. 2008;7(6)b Suppl. 1:173. (In Russ.) [Кахраманова С.М., Бахшалиев А.Б. Антигипертензивная и кардиопротективная эффективность Экватора у больных эссенциальной гипертонией. «Российский национальный конгресс кардиологов. Повышение качества и доступности кардиологической помощи (материалы конгресса)». Кардиоваскулярная Терапия и Профилактика. 2008;7(6)б Приложение 1:173].

38. Ivanov K.M., Rybchinskaya I.I. Combined therapy of essential hypertension by drug Equator in patients with postsurgical hypothyroidism. Ural'skij Medicinskij Zhurnal. 2011;2:119-23. (In Russ.) [Иванов К.М., Рыбчинская И.И. Комбинированная терапия гипертонической болезни препаратом Экватор у больных с послеоперационным гипотиреозом. Уральский Медицинский Журнал. 2011;2:119-23].

39. Ageev F.T., Ovchinnikov A.G., Serbul V.M., Belenkov Ju.N. Left ventricle hypertrophy: the role of the renin-angiotensin system. Cardiovascular Therapy and Prevention. 2008;7(2):98-108. (In Russ.) [Агеев Ф.Т., Овчинников А.Г., Сербул В.М., Беленков Ю.Н. Гипертрофия левого желудочка: роль ренин-ангиотензиновой системы. Кардиоваскулярная Терапия и Профилактика. 2008;7(2):98-108].

40. Krikunov P.V., Vasjuk Ju.A., Kopeleva M.V., Krikunova O.V. Left ventricle hypertrophy as a target for therapeutic intervention. Diagnostic and treatment aspects. Serdce. 2008;6(7):324-34. (In Russ.) (Крикунов П.В., Васюк Ю.А., Копелева М.В., Крикунова О.В. Гипертрофия левого желудочка как мишень для терапевтического вмешательства. Особенности диагностики и лечения. Сердце. 2008;6(7):324-34].

41. Abaturova O.V., Kremneva L.V., Shalaev S.V. Hypertrophy of the left ventricle: the role of hemodynamic and neurohormonal factors, the molecular-cellular mechanisms of development. Ural'skij meditsinskij zhurnal. Meditsinskaja Nauka i Praktika. 2004;7:11-6. (In Russ.) [Абатурова О.В., Кремнева Л.В., Шалаев С.В. Гипертрофия миокарда левого желудочка: роль гемодинамических и нейрогормональных факторов, молекулярно-клеточные механизмы развития. Уральский медицинский журнал. Медицинская Наука и Практика. 2004;7:11-6].

42. Chudinovskih Ju.A., Eremeeva M.V., Suhacheva T.V., et al. The new data on the mechanisms of the effect of pharmacological treatment on myocardial hypertrophy in patients with obstructive form of hypertrophic cardiomyopathy. Klinicheskaya Fiziologiya Krovoobrashheniya. 2013;1:12-8. (In Russ.) [Чудиновских Ю.А., Еремеева М.В., Сухачева Т.В., и др. Новые данные о механизмах влияния фармакологического лечения на гипертрофию миокарда у пациентов с обструктивной формой гипертрофической кардиомиопатии. Клиническая Физиология Кровообращения. 2013;1:12-8].

43. Davies C.H., Harding S.E., Poole-Wilson P.A. Cellular mechanisms of contractile dysfunction in human heart failure. Eur Heart J. 1996;17(2):189-98. doi: 10.1093/oxfordjournals.eurheartj.a014834.

44. Berglund T. Differential Regression of Electrocardiographic Left Ventricular Hypertrophy by Amlodipine Versus Atenolol in the ASCOT Trial. 18th Scientific Meeting of the European Society of Hypertension 2008;Abstract PS17. J Hypertens. 2008;26(suppl 1):S254. Abstract PS17/TUE/05.

45. Dahlöf B., Pennert K., Hansson L. Reversal of left ventricular hypertrophy in hypertensive patients: a metaanalysis of 109 treatment studies. American Journal of Hypertension. 1992;5(2):95-110. doi: 10.1093/ajh/5.2.95.

46. Schmieder R.E., Schlaich M.P., Klingbeil A.U., Martus P. Update on reversal of left ventricular hypertrophy in essential hypertension (a meta-analysis of all randomized double-blind studies until December 1996). Nephrol Dial Transplant. 1998 Mar;13(3):564-9. doi: 10.1093/ndt/13.3.564.

47. Fagard R.H., Celis H., Thijs L., Wouters S. Regression of left ventricular mass by antihypertensive treatment. Hypertension. 2009;54(5):1084-91. doi: 10.1161/HYPERTENSIONAHA.109.136655.

48. Leonova M.V. Modern Approaches to Treat Arterial Hypertension with beta-Blockers. Lechebnoe Delo. 2012;2:14-20. (In Russ.) [Леонова М. В. Современные аспекты применения бета-блокаторов в лечении артериальной гипертонии. Лечебное Дело. 2012;2:14-20].

49. Diez J., Lopez B., Gonzales A., Querejeta R. Clinical aspects of hypertensive myocardial fibrosis. Curr Opin Cardiol. 2001;16:328-335. doi: 10.1097/00001573-200111000-00003.

50. Weber K.T., Brilla C.G., Janicki J.S. Myocardial fibrosis: functional significance and regulatory factors. Cardiovasc Res. 1993;27:341-8. doi: 10.1093/cvr/27.3.341.

51. Diez M. Mechanisms of cardiac fibrosis in hypertension. J Clin Hypertens. 2007;9:546-50. doi: 10.1111/j.1524-6175.2007.06626.x.

52. Borlaug B.A., Lam C.S., Roger V.L., et al. Contractility and ventricular systolic stiffening in hypertensive heart disease. Insights into the pathogenesis of heart failure with preserved ejection fraction. J Am Coll Cardiol. 2009;54:410-8. doi: 10.1016/j.jacc.2009.05.013.

53. Tsai W.C., Huang Y.Y., Liu Y.W., et al. Changes of left atrial phasic function assessed by speckle tracking echocardiography in untreated hypertension. Journal of Medical Ultrasound 2012;20:220-7. doi: 10.1016/j.jmu.2012.10.010.

54. Lang R.M., Badano L.P., Mor-Avi V., et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015;28(1):1-39.e14. doi: 10.1016/j.echo.2014.10.003.

55. Tsang T.S., Barnes M.E., Abhayaratna W.P., et al. Effects of quinapril on left atrial structural remodeling and arterial stiffness. Am J Cardiol. 2006;97:916-20. doi: 10.1016/j.amjcard.2005.09.143.

56. Brilla C.G., Funck R.C., Rupp H. Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease. Circulation. 2000;102:1388-93. doi: 10.1161/01.CIR.102.12.1388.

57. Diez J., Laviades C., Mayor G., et al. Increased serum concentrations of procollagen peptides in essential hypertension: relation to cardiac alterations. Circulation. 1995;91:1450-6. doi: 10.1161/01.CIR.91.5.1450.

58. Xing S.S., Tan H.W., Bi X.P., et al. Felodipine reduces cardiac expression of IL-18 and perivascular fibrosis in fructose-fed rats. Mol Med. 2008;14(7-8):395-402. doi: 10.2119/2008-00024.Xing.

59. Siddesha J.M., Valente A.J., Sakamuri S.S., et al. Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK. J Cell Physiol. 2014;229(7):845-55. doi: 10.1002/jcp.24511


For citation:


Ostroumova O.D., Kochetkov A.I., Kopchjonov I.I., Fomina V.M. ARTERIAL HYPERTENSION IN THE PRESENCE OF OVERWEIGHT AND OBESITY. THE CAPABILITIES OF AMLODIPINE AND LISINOPRIL COMBINATION. Part 2. Antihypertensive and Organoprotective Effects of Amlodipine/Lisinopril Fixed-Dose Combination in Patients with Arterial Hypertension in the Presence of Overweight and Obesity. Rational Pharmacotherapy in Cardiology. 2017;13(6):841-850. (In Russ.) https://doi.org/10.20996/1819-6446-2017-13-6-841-850

Views: 283


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)