Rational Pharmacotherapy in Cardiology

Advanced search


Full Text:


Aim. To study the incidence of arterial hypertension (HT) and prevalence of risk factors and occupational factors (OF) among people with HT on the base of engineering plant within "The program of formation of healthy lifestyle and prevention of chronic non-communicable diseases among the contingent, attached for the medical assistance for the period 2012-2016".

Material and methods. The study included men (n=586), aged 20-65 years – the workers of the engineering plant directly involved in the works in conditions of industrial occupational exposures. These specified works occupied not less than 50% of the general time, and work experience at the enterprise in examined workers was at least 5 years.

Results. All examined people were divided into 2 groups according to the office blood pressure (BP) levels: without HT – 380 people (64.8%) and with HT – 206 patients (35.2%). HT was observed more often among people without higher education (39.2 vs 28.3%; р<0.07). The prevalence of morphological changes on the fundus of eyes was significantly different in hypertensive patients and people without HT (30.6% vs 21.3%, respectively; p<0.04), that appears to be evidence of early organ disorders. OF were found more often in the group of workers with elevated office BP (31.9% vs 23.2%; p<0.04). Metabolic syndrome were detected in 44.8% of hypertensive patients vs 22.4% in people without HT (p<0.001). The people with HT but without other components of metabolic syndrome were taken for particular analysis. In this group the higher education was also much less often (24.0% vs 57.6%; p<0.001), and OF (excluding work at the computer) were revealed more often (87.3% vs 80.2%; p <0.06).

Conclusion. The development of HT in workers of engineering plant is influenced, firstly, by "traditional" risk factors – age and components of metabolic syndrome, and higher education is a kind of HT "anti-risk factor". OF were significantly more common in the group of workers with elevated office BP. Periodic checkups should be the routine method to identify chronic non-communicable diseases among people of working age.

About the Authors

A. N. Britov
National Medical Research Center for Preventive Medicine
Russian Federation

Anatoly N. Britov – MD, PhD, Professor, Head of Laboratory of Arterial Hypertension Prevention, Department of Primary Prevention of Chronic Non-Communicable Diseases in the Healthcare System 

Petroverigsky per. 10, Moscow, 101990

S. A. Tjupaeva
Plant Medical-Sanitation Unit №170, Federal Medical-Biological Agency of Russia
Russian Federation

Svetlana A. Tjupaeva – MD, Head Therapeutic Department 

Lenina ul. 2, Korolev, Moscow Region, 141070

N. A. Eliseeva
National Medical Research Center for Preventive Medicine
Russian Federation

Nina A. Eliseeva – MD, PhD, Senior Researcher, Laboratory of Arterial Hypertension Prevention, Department of Primary Prevention of Chronic Non-Communicable Diseases in the Healthcare System 

Petroverigsky per. 10, Moscow, 101990

A. N. Meshkov
National Medical Research Center for Preventive Medicine
Russian Federation

Alexey N. Meshkov – MD, PhD, Head of Laboratory of Molecular Genetics 

Petroverigsky per. 10, Moscow, 101990

A. D. Deev
National Medical Research Center for Preventive Medicine
Russian Federation

Alexander D. Deev – PhD (in Physics and Mathematics), Head of Laboratory of Biostatistics, Department of Epidemiology of Chronic Non-Communicable Diseases 

Petroverigsky per. 10, Moscow, 101990


1. Global strategy for prevention and control of non-communicable diseases. Geneva: World Health Organization; 2014.

2. Kontcevaja A.V., Shalnova S.A., Balanova Ju.V., Deev A.D. The quality of life of Russian population as data of ESSE-RF study. Cardiovascular Therapy and Prevention. 2016;15(5):84-90. (In Russ.) [Концевая А.В., Шальнова С.А., Баланова Ю.А, Деев А.Д. Качество жизни российской популяции по данным исследования ЭССЕ-РФ. Кардиоваскулярная Терапия и Профилактика. 2016;15(5):8490] doi: 10.15829/1728-8800-2016-5-84-90.

3. Sidorenko B.A., Preobrajenskiy D.V., Romanova N.E. et al. Hypertensive disease in elderly age patients: prevalence, clinical significance and drug therapy. Kardiologia. 1999;12:71-84 (In Russ.) [Сидоренко Б.А., Преображенский Д.В., Романова Н.Е. и др. Гипертоническая болезнь в пожилом возрасте: распространенность, клиническое значение и медикаментозная терапия// Кардиология. 1999;12:71-84].

4. Heart disease and Stroke statistics-2012 update: a report from the American Heart Association// Circulation 2012;125(1):2-220. doi: 10.1161/CIR.0b013e31823ac046.

5. Cook J.R., Glick H.A., Gerth W., et al. The cost and cardioprotective effects of enalapril in hypertensive patients with left ventricular dysfunction. Am J Hypertens. 1998;11(12):1433-41. doi: 10.1016/S0895-7061(98)00180-0.

6. Doshchitsin V.L., Drapkina O.M. Arterial hypertension in metabolic syndrome. Russian Journal of Cardiology. 2006;5(61):64-7 (In Russ.) [Дощицин В.Л., Драпкина О.М. Артериальная гипертензия при метаболическом синдроме. Российский Кардиологический Журнал. 2006;5(61):64-7]. doi: 10.15829/1560-4071-2006-5-64-67.

7. Reaven G. Role of insulin resistance in human disease. Diabetes. 1988;37:1595-607.

8. Chazova I.E., Mychka V.B. Metabolic syndrome. Moscow: Media Medica; 2004. (In Russ.) [Чазова И.Е., Мычка В.Б. Метаболический синдром. М.: Media Medica; 2004].

9. Melnichenko G.A. Obesity in practice of endocrinologist. Russkij Medicinskij Zhurnal. 2001;2(9):82-7. (In Russ.) [Мельниченко Г.А. Ожирение в практике эндокринолога. Русский Медицинский Журнал. 2001;2(9):82-7].

10. Magliano D.J., Shaw J.E., Zimmet P.Z. How to best define the metabolic syndrome. Ann Med. 2006;38(1):34-41; doi: 10.1080/07853890500300311.

11. Mamedov M.N. Metabolic syndrome is more than risk factor combination: the principles of diagnosis and treatment. Moscow: Vervagpharma; 2006 (In Russ.) [Мамедов М.Н. Метаболический синдром больше, чем сочетание факторов риска: принципы диагностики и лечения. М.: Вервагфарма; 2006].

12. Oganov R., Mamedov M., Koltunov I. Metabolic syndrome: the way from science concept to clinical diagnosis. Vrach. 2007;3:3-7 (In Russ.) [Оганов Р, Мамедов М., Колтунов И. Метаболический синдром: путь от научной концепции до клинического диагноза. Врач 2007;3:3-7].

13. Tsfasman A.Z. Professional Cardiology. Moscow: Reprotsentr M; 2007. (in Russ.) [Цфасман А.З. Профессиональная кардиология. М.: Репроцентр М; 2007].

14. Izmerov N.F., Skvirskaja G.P. The work environment as risk factor of cardiovascular morbidity and mortality. Bulletin of the East Siberian Scientific Center SBRAMS. 2005;2(40):14-20 (In Russ.) [Измеров Н.Ф., СквирскаяГ.П. Условия труда как фактор риска развития заболеваний и смертности от сердечно-сосудистой патологии. Бюллетень ВПНЦ СО РАМН. 2005;2(40):14-20].

15. Gaynulin Sh.M., Lazebnik L.B., Drozdov V.N. Compatibility modifiable risk factors in patients with arterial hypertension identified during the target examination. Russian Journal of Cardiology. 2006;4(60):51-3 (In Russ.) [Гайнулин Ш.М., Лазебник Л.Б., Дроздов В.Н. Сочетаемость корригируемых факторов риска у больных с артериальной гипертонией, выявленной при целевой диспансеризации. Российский Кардиологический Журнал. 2006;4(60):51-3].

16. 2.2.2006-05 Occupational health. Guidance on hygienic assessment of working environment factors of the work process. Criteria and classification of working conditions. Available at: Checked by 12/10/2017 (In Russ.) [2.2.2006-05 Гигиена труда. Руководство по гигиенической оценке факторов рабочей среды трудового процесса. Критерии и классификация условий труда. Доступно на: Проверено 10.12.2017].

17. Britov A.N., Eliseeva N.A., Deev A.D., et al. Psycho-social factors in assessment of public health as the results of multicentre population study. Preventive Medicine. 2012;15(1):4-9. (In Russ.) [Бритов А.Н., Елисеева Н.А., Деев А.Д. и др. Психосоциальные факторы в оценке общественного здоровья по результатам популяционного многоцентрового исследования. Профилактическая Медицина. 2012;15(1):4-9].

18. Britov A.N., Eliseeva N.A., Deev A.D. et al. «Impact of psychological factors on integral characteristic of health. Prospective population study data». Klin Med. 2015;93(1):56-2 (In Russ.) [Бритов А.Н., Елисеева Н.А., Деев А.Д. с др. Влияние психологических факторов на интегральную характеристику здоровья. Данные проспективного популяционного исследования. Клиническая Медицина. 2015;93(1):56-2].

19. Erina A.M., Rotar O.P., Orlov A.V., et al. Prehypertension and cardiometabolic risk factors (data of the ESSE-RF study). Arterial Hypertension. 2017;23(3):243-52 (In Russ.) [Ерина А.М., Ротарь О.П., Орлов А.В., и др. Предгипертензия и кардиометаболические факторы риска (по материалам исследования ЭССЕ-РФ). Артериальная Гипертензия. 2017;23(3):243-52]. doi:10.18705/1607-419X-2017-23-3-243-252.

20. Izmerov N.F. Modern problems of occupational medicine. Vestnik RAMN 2006; 9 (10): 50-56 (In Russ.) [Измеров Н.Ф. Современные проблемы медицины труда. Вестник РАМН. 2006; 9(10):50-6]

21. Velichkovskiy B. T. Social stress, labor motivation and health. Vestnik Smolenskoj Gosudarstvennoj Medicinskoj Akademii. 2006; 6:8-14. (In Russ.) [Величковский Б.Т. Социальный стресс, трудовая мотивация и здоровье. Вестник Смоленской Государственной Медицинской Академии. 2006;6:8-14].

22. Folkov B. Mental stress and its importance for the development of cardiovascular diseases. Kardiologiia. 2007;10:4-11. (In Russ.) [Фолков Б. Эмоциональный стресс и его значение для развития сердечно-сосудистых заболеваний. Кардиология. 2007;10:4-11].

For citation:

Britov A.N., Tjupaeva S.A., Eliseeva N.A., Meshkov A.N., Deev A.D. RISK FACTORS OF ARTERIAL HYPERTENSION IN ORGANIZED COHORT OF MALE EMPLOYEES OF THE MACHINE BUILDING PLANT. Rational Pharmacotherapy in Cardiology. 2017;13(6):800-805. (In Russ.)

Views: 163

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)