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PRACTICAL ASPECTS OF APIXABAN USE IN CLINICAL PRACTICE: VIEW POINT OF CLINICAL PHARMACOLOGIST

https://doi.org/10.20996/1819-6446-2015-11-2-209-216

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Abstract

Apixaban is a "new" oral anticoagulant, direct Xa factor inhibitor with a good evidence base of the efficacy in the prevention of ischemic stroke in patients with atrial fibrillation. The article is devoted to apixaban use in clinical practice: examination before apixaban administration, clinical situation when laboratory control and monitoring are needed, drugs interactions (at the level of CYP3A4, P-gp), management of patients with bleeding because of apixaban therapy (including antidotes application), perioperative management of patients receiving apixaban.

About the Authors

D. A. Sychev
Russian Medical Academy of Postgraduate Education
Russian Federation
Barricadnaya ul. 2/1, Moscow, 123995 Russia


I. I. Sinitsina
Russian Medical Academy of Postgraduate Education
Russian Federation
Barricadnaya ul. 2/1, Moscow, 123995 Russia


G. Yu. Zakharova
Russian Medical Academy of Postgraduate Education
Russian Federation
Barricadnaya ul. 2/1, Moscow, 123995 Russia


M. I. Savel'eva
Russian Medical Academy of Postgraduate Education
Russian Federation
Barricadnaya ul. 2/1, Moscow, 123995 Russia


A. V. Ryabova
Russian Medical Academy of Postgraduate Education
Russian Federation
Barricadnaya ul. 2/1, Moscow, 123995 Russia


A. V. Kryukov
Russian Medical Academy of Postgraduate Education
Russian Federation
Barricadnaya ul. 2/1, Moscow, 123995 Russia


A. Yu. Yurovskii
Russian Medical Academy of Postgraduate Education
Russian Federation
Barricadnaya ul. 2/1, Moscow, 123995 Russia


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For citation:


Sychev D.A., Sinitsina I.I., Zakharova G.Y., Savel'eva M.I., Ryabova A.V., Kryukov A.V., Yurovskii A.Y. PRACTICAL ASPECTS OF APIXABAN USE IN CLINICAL PRACTICE: VIEW POINT OF CLINICAL PHARMACOLOGIST. Rational Pharmacotherapy in Cardiology. 2015;11(2):209-216. (In Russ.) https://doi.org/10.20996/1819-6446-2015-11-2-209-216

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