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Assessment of the left atrial (LA) function is important aspect of comprehensive cardiovascular system estimation. Many cardiac diseases make an impact to LA work either by direct affect on myocardium or hemodynamic condition changing. It is considered, LA and left ventricle diastolic pressure is interrelated, thus without mitral valve disease LA expanding is a sign of LV filling pressure augmentation. Examination of LA size and function by analysis of atrial reservoir, conduit, and booster pump can predict cardiovascular outcomes in patients with cardiomyopathy, ischemic heart disease and valvular heart disease. The last two decades gave new technologies to accurate and comprehensive LA mechanics estimation, in the first place related to tissue Doppler imaging. Atrial strain and strain rate obtained using two-dimensional speckle-tracking echocardiography have proved to be feasible and reproducible techniques to evaluate LA mechanics.

In physiological settings, LA is a highly expandable chamber with relatively low pressures. However in the presence of acute and chronic injury, LA wall stretches. LA stretching is a hallmark of structure changing with myocardial fibrosis and has influence on LA strain and strain rate. LA strain estimation could be useful in the prediction of sinus rhythm restoration and maintenance after cardioversion and catheter ablation. Low values of global longitudinal LA strain indicate irreversible LA remodeling and are related to the atrial fibrillation progression from paroxysmal to permanent forms. The most interesting in these circumstances is the potential contribution of echocardiography to thromboembolic risk stratification in atrial fibrillation and invasive procedures such as atrial ablation. Therefore, at present, the main task is to understand the ways of clinical application of data  obtained during the LA study.

About the Authors

E. N. Pavlyukova
Cardiology Research Institute, Tomsk National Research Medical Centre
Russian Federation

Elena N. Pavlyukova – MD, PhD, Professor, Leading Researcher, Department of Atherosclerosis and Chronic Ischemic Heart Disease.

Kievskaya ul. 111A, Tomsk, 634012

D. A. Kuzhel
Krasnoyarsk State Medical University named after Prof. V.F. Voyno-Yasenetsky; Krasnoyarsk Territory Hospital №2
Russian Federation

Dmitry A. Kuzhel – MD, PhD, Associate Professor, Chair of Cardiology and Functional Diagnostic.

Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022; Karla Marxa ul. 43,  Krasnoyarsk, 660097

G. V. Matyushin
Krasnoyarsk State Medical University named after Prof. V.F. Voyno-Yasenetsky
Russian Federation

Gennady V. Matyushin – MD, PhD, Professor, Head of Chair of Cardiology and Functional Diagnostic.

Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022


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For citations:

Pavlyukova E.N., Kuzhel D.A., Matyushin G.V. LEFT ATRIAL FUNCTION: MODERN ASSESSMENT METHODS AND CLINICAL SIGNIFICANCE. Rational Pharmacotherapy in Cardiology. 2017;13(5):675-683. (In Russ.)

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