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AGE AND GENDER PECULIARITIES OF BLOOD LIPIDS IN URBAN RESIDENTS (CROSS-SECTIONAL STUDY RESULTS)

https://doi.org/10.20996/1819-6446-2017-13-5-637-644

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Abstract

Aim. To analyze the results of measurements of the blood lipid spectrum of urban  residents of the European part of the Russian Federation.

Material and methods. The results of single assessment of lipid profiles in 22,436 males and 35,100 females at the age from 13 to 94 years in 347 cities and towns  of the European part of the Russian Federation were analyzed. Lipid assays were performed by the Laboratory Service «HELIX» from 28 Jan 2015 to 19 Mar 2016.

Statistical methods included descriptive statistics, the analysis of distributions of sample comparisons and the search of dependencies.

Results. Results of 56,235 measurements of total cholesterol (TC), 22,641 – triglycerides (TG), 21,032 – high density lipoproteins cholesterol (HDL-C) and 22,441 – low density lipoprotein cholesterol (LDL-C) were analyzed. TC above 5.2 mmol/l was identified in 55.78% samples; the proportion of people with LDL-C level above 3.0 mmol/l was 62.95%. The level of TC was the highest at the age of 43 to 62 years in both men and women, while the peak in the increase in TC in men was approximately 10 years earlier, than  in women. In patients of older age groups, TC levels decreased and reached minimum values in men and women of senile age and long-livers. Low level of HDL-C was observed in 24.46% of the total number of samples in men and in 17.68% – in women. The monotonous increase in the average levels of HDL-C was revealed in men with aging. In women the HDL-C levels increased sharply from a minimum at the age of 13 years to a maximum at the age of 25 years with a slight monotonous decrease in the following age periods. However, even in the age older than 83 years levels of HDL-C remained high (1.49 mmol/l in average). The level of TG showed significant inter-age fluctuations, especially in men. The levels of TG above 1.7 mmol/l were recorded in 30.07% of all cases.

Conclusion. Two-factor analysis of variance for all lipid parameters revealed a high statistical significance of gender and age.

About the Authors

S. A. Urazgildeeva
Clinical, Research and Education Center "Cardioilogy", Saint-Petersburg State University; Center for Atherosclerosis and Lipid Disorders, Clinical Hospital №122 named after L.G Sokolov, Federal Medical and Biological Agency
Russian Federation

Soreya A. Urazgildeeva – MD, PhD, Leading Researcher,  Department of Atherosclerosis Clinical REC"Cardioilogy" SPSU; Cardiologist CALD CH №122 L.G Sokolov.

Universitetskaya nab. 7-9, Saint-Petersburg, 199034; Kulturny prosp. 4, Saint-Petersburg, 194291 



M. Yu. Nizhegorodcev
Laboratory Service "HELIX"
Russian Federation

Maxim Yu. Nizhegorodcev – MD, PhD, Cardiologist.

Sampsonievsky prosp. 20-A, Saint-Petersburg, 194044



P. S. Sadovnikov
Laboratory Service "HELIX"
Russian Federation

Pavel S. Sadovnikov – Project Manager, Technology Division.

Sampsonievsky prosp. 20-A, Saint-Petersburg, 194044



A. Yu. Olkhovik
Laboratory Service "HELIX"
Russian Federation

Andrei Yu. Olkhovik – Specialist, Technology Division.

Sampsonievsky prosp. 20-A, Saint-Petersburg, 194044



D. Yu. Nokhrin
Chelyabinsk State University
Russian Federation

Denis Yu. Nokhrin – PhD (in Biology), Associate Professor, Chair of Microbiology, Immunology and General Biology, Biological Faculty.

Bratiyev Kashirinych ul. 129, Chelyabinsk, 454001



M. V. Muzalevskaya
Center for Atherosclerosis and Lipid Disorders, Clinical Hospital №122 named after L.G Sokolov, Federal Medical and Biological Agency
Russian Federation

Maria  V. Muzalevskaya – MD, Cardiologist, Center for Atherosclerosis and Lipid Disorders.

Kulturny prosp. 4, Saint-Petersburg, 194291



I. V. Shugurova
Center for Cardiac Medicine "Chernaya rechka"
Russian Federation

Irina V. Shugurova – MD, Head of Diagnostic Center.

Primorskoye schosse  648, Molodezhnoye pos., Saint Petersburg, 197729



D. G. Malenkovskaya
Center for Atherosclerosis and Lipid Disorders, Clinical Hospital №122 named after L.G Sokolov, Federal Medical and Biological Agency
Russian Federation

Diana G. Malenkovskaya – MD, Cardiologist.

Kulturny prosp. 4, Saint-Petersburg, 194291



A. V. Tregubov
Clinical, Research and Education Center "Cardioilogy", Saint-Petersburg State University Center for Atherosclerosis and Lipid Disorders, Clinical Hospital №122 named after L.G Sokolov, Federal Medical and Biological Agency
Russian Federation

Aleksey V. Tregubov – MD, Junior Researcher,  Clinical, Research and Education Center "Cardioilogy", Saint-Petersburg State University; Cardiologist CALD CH №122 L.G Sokolov.

Universitetskaya nab. 7-9, Saint-Petersburg, 199034; Kulturny prosp. 4, Saint-Petersburg, 194291



V. S. Gurevich
Clinical, Research and Education Center "Cardioilogy", Saint-Petersburg State University; Center for Atherosclerosis and Lipid Disorders, Clinical Hospital №122 named after L.G Sokolov, Federal Medical and Biological Agency; North-Western State Medical University named after I.I Mechnikov
Russian Federation

Victor S. Gurevich – MD, PhD, Professor, Head of Department of Atherosclerosis C REC "Cardioilogy"SPSU; Head CALD CH №122 L.G Sokolov;  Pofessor Chair of Hospital Therapy and Cardiology named after М.S. Kushakovsky NWSMU I.I. Mechnikov.

Universitetskaya nab. 7-9, Saint-Petersburg, 199034; Kulturny prosp. 4, Saint-Petersburg, 194291; Kirochnaya ul. 41,  Saint-Petersburg, 191015



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For citation:


Urazgildeeva S.A., Nizhegorodcev M.Y., Sadovnikov P.S., Olkhovik A.Y., Nokhrin D.Y., Muzalevskaya M.V., Shugurova I.V., Malenkovskaya D.G., Tregubov A.V., Gurevich V.S. AGE AND GENDER PECULIARITIES OF BLOOD LIPIDS IN URBAN RESIDENTS (CROSS-SECTIONAL STUDY RESULTS). Rational Pharmacotherapy in Cardiology. 2017;13(5):637-644. (In Russ.) https://doi.org/10.20996/1819-6446-2017-13-5-637-644

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