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CLINICAL ADVANTAGES OF TELMISARTAN: FEATURES OF PHARMACOKINETICS, PHARMACODYNAMICS AND EFFECTS ON THE DAILY BLOOD PRESSURE PROFILE

https://doi.org/10.20996/1819-6446-2017-13-4-550-557

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Abstract

The features of the pharmacokinetics of the angiotensin II receptor blocker telmisartan are considered. Thanks to these features it has a number of advantages in comparison with other angiotensin II receptor blockers and antihypertensive drugs from other classes. Particular attention is paid to the long half-life of telmisartan, which retains its effect for more than 24 hours. This is especially important for controlling blood pressure (BP) in the early morning hours. Data from studies demonstrating that excessive BP rises in the early morning hours increase the risk of cardiovascular and cerebrovascular complications are presented. The results of comparative studies of telmisartan using the ambulatory BP monitoring, which testify to its advantages in BP control within 24-hours, are considered.

About the Authors

O. D. Ostroumova
A.I. Evdokimov Moscow State University of Medicine and Dentistry; I.M. Sechenov First Moscow State Medical University
Russian Federation

MD, PhD, Professor, Chair of Faculty Therapy and Occupational Diseases, Delegatskaya ul. 20-1, Moscow, 127473;

Chair of Clinical Pharmacology and Propaedeutics of Internal Diseases, Trubetskaya ul. 8-2, Moscow, 119991



E. A. Smolyarchuk
I.M. Sechenov First Moscow State Medical University
Russian Federation

MD, PhD, Associate Professor, Chair of Clinical Pharmacology and Propaedeutics of Internal Diseases,

Trubetskaya ul. 8-2, Moscow, 119991



O. V. Bondarec
A.I. Evdokimov Moscow State University of Medicine and Dentistry
Russian Federation

MD, PhD, Associate Professor, Chair of Faculty Therapy and Occupational Diseases,

Delegatskaya ul. 20-1, Moscow, 127473



E. E. Paleeva
A.I. Evdokimov Moscow State University of Medicine and Dentistry
Russian Federation

MD, PhD, Assistant, Chair of Faculty Therapy and Occupational Diseases, 

Delegatskaya ul. 20-1, Moscow, 127473



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For citation:


Ostroumova O.D., Smolyarchuk E.A., Bondarec O.V., Paleeva E.E. CLINICAL ADVANTAGES OF TELMISARTAN: FEATURES OF PHARMACOKINETICS, PHARMACODYNAMICS AND EFFECTS ON THE DAILY BLOOD PRESSURE PROFILE. Rational Pharmacotherapy in Cardiology. 2017;13(4):550-557. (In Russ.) https://doi.org/10.20996/1819-6446-2017-13-4-550-557

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ISSN 1819-6446 (Print)
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