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COMPARATIVE RESULTS OF RECOMBINANT NON-IMMUNOGENIC STAPHYLOKINASE AND TENECTEPLASE USE IN ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN REAL CLINICAL PRACTICE

https://doi.org/10.20996/1819-6446-2017-13-4-463-468

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Abstract

Aim. To compare the efficacy and safety of thrombolytic therapy with recombinant non-immunogenic staphylokinase and tenecteplase in ST elevation myocardial infarction (STEMI) in real clinical practice.

Material and methods. 84 patients with onset of STEMI symptoms up to 12 hours ago were included into the non-experimental study with mixed design. Recombinant non-immunogenic staphylokinase and tenecteplase were used in 38 and 46 patients, respectively. The dynamics of the ST segment on the ECG, angiographic reperfusion criteria were evaluated as well as clinical outcomes – mortality, reinfarction, stroke, bleeding and allergic reactions.

Results. The ST-segment resolution by 70% after 180 min was achieved in 66% and 66% of patients in recombinant non-immunogenic staphylokinase group and in tenecteplase group, respectively (p=0.66) as well as antegrade coronary blood flow through the infarct-related artery TIMI II-III in 61% and 67% of patients, respectively (p=0.63). Mortality and the rate of reinfarction, intracranial bleeding, stroke, cardiogenic shock, left ventricle aneurism and thrombosis were similar in both groups. Large bleeding (otherwise intracranial one) and allergic reactions were not registered.

Conclusion. In real clinical practice the efficacy and safety of recombinant non-immunogenic staphylokinase and tenecteplase in STEMI are similar. 

About the Authors

E. S. Mazur
Tver State Medical University
Russian Federation

MD, PhD, Professor, Head of Chair of Hospital Therapy,

Sovetskaya ul. 4, Tver, 170100 



R. M. Rabinovich
Regional Clinic Hospital
Russian Federation

MD, PhD, Head of Cardiology Department with Intensive Care Unit,

Sankt-Peterburgskoe shosse 105, Tver, 170036



V. V. Mazur
Tver State Medical University
Russian Federation

MD, PhD, Professor, Chair of Hospital Therapy and Occupational Diseases,

Sovetskaya ul. 4, Tver, 170100 



N. S. Kuznetsova
Tver State Medical University
Russian Federation

MD, Post-Graduate Student, Chair of Hospital Therapy,

Sovetskaya ul. 4, Tver, 170100 



E. A. Kudryashova
Regional Clinic Hospital
Russian Federation

MD, Cardiologist,

Sankt-Peterburgskoe shosse 105, Tver, 170036



S. V. Veselov
Tver State Medical University
Russian Federation

MD, PhD, Assistant, Chair of Pharmacology and Clinical Pharmacology,

Sovetskaya ul. 4, Tver, 170100 



V. V. Bobkov
Regional Clinic Hospital
Russian Federation

MD, PhD, Deputy Chief Physician for Management of Regional Vascular Center,

Sankt-Peterburgskoe shosse 105, Tver, 170036



D. Yu. Platonov
Tver State Medical University; Regional Clinic Hospital
Russian Federation

MD, PhD, Head of Chair of Internal Medicine, Faculty of Postgraduate Studies, Sovetskaya ul. 4, Tver, 170100 ;

Head of Cardiology Department, Tver Regional Clinic Hospital, Sankt-Peterburgskoe shosse 105, Tver, 170036



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For citation:


Mazur E.S., Rabinovich R.M., Mazur V.V., Kuznetsova N.S., Kudryashova E.A., Veselov S.V., Bobkov V.V., Platonov D.Y. COMPARATIVE RESULTS OF RECOMBINANT NON-IMMUNOGENIC STAPHYLOKINASE AND TENECTEPLASE USE IN ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN REAL CLINICAL PRACTICE. Rational Pharmacotherapy in Cardiology. 2017;13(4):463-468. (In Russ.) https://doi.org/10.20996/1819-6446-2017-13-4-463-468

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