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ANGIOTENSIN RECEPTOR BLOCKERS WITH PLEIOTROPIC PROPERTIES: A NEW STANDARD IN CARDIOVASCULAR RISK MANAGEMENT AND TREATMENT OF HYPERTENSION

https://doi.org/10.20996/1819-6446-2017-13-3-383-390

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Abstract

An increase in the activity of the renin-angiotensin-aldosterone system is one of the most important mechanisms for the realization of the cardiovascular continuum. The role that angiotensin receptor blockers play in achieving target figures of blood pressure and reducing cardiovascular risk is discussed. The importance of pleiotropic properties of angiotensin receptor blockers (in particular, activation of peroxisome proliferator-activated receptors gamma – PPAR-γ) in the management of patients with insulin resistance, obesity, dyslipidemia is also covered. The evidence base for the use of telmisartan as a drug with pleiotropic effect in patients with arterial hypertension and associated diseases (diabetes mellitus, obesity, renal dysfunction) is discussed. 

About the Authors

V. I. Podzolkov
I.M. Sechenov First Moscow State Medical University
Russian Federation
Valery I. Podzolkov - MD, PhD, Professor, Head of Chair of Faculty Therapy N2, Director of the Therapeutic Clinic of University Clinical Hospital №4


M. V. Pisarev
I.M. Sechenov First Moscow State Medical University
Russian Federation

 Mikhail V. Pisarev - MD, PhD, Associate Professor, Chair of Faculty Therapy N2 

Trubetskaya ul. 8-2, Moscow, 119991



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For citation:


Podzolkov V.I., Pisarev M.V. ANGIOTENSIN RECEPTOR BLOCKERS WITH PLEIOTROPIC PROPERTIES: A NEW STANDARD IN CARDIOVASCULAR RISK MANAGEMENT AND TREATMENT OF HYPERTENSION. Rational Pharmacotherapy in Cardiology. 2017;13(3):383-390. (In Russ.) https://doi.org/10.20996/1819-6446-2017-13-3-383-390

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