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LIS-3 REGISTER OF THE ACUTE CORONARY SYNDROME: WHAT HAS CHANGED IN A "PORTRAIT" OF A PATIENT AND SHORT-TERM OUTCOMES OF THE DISEASE COMPARED TO LIS-1 REGISTER

https://doi.org/10.20996/1819-6446-2017-13-1-63-68

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Abstract

Aim. To compare a «portrait» of a patient and hospital lethality between register LIS-1 of myocardial infarction (MI) and register LIS-3 of acute coronary syndrome (ACS).

Material and methods. We compared two registers held in Lubertsy town: MI register LIS-1 (2005-2007) and ACS register LIS-3 (01.11.2013-31.07.2015). LIS-1 is a retrospective study; information about patients survived and died in hospital was taken from medical histories. LIS-3 is a prospective study; data on survived patients was collected from questionnaires and medical histories, information about died ones – from medical histories.

Results. «Portrait» of a patient of LIS-1 and LIS-3 registers was comparable in gender, age, history of MI, arterial hypertension, atrial fibrillation, and stroke. LIS-3 patients had diabetes mellitus more often, and on the contrary, history of ischemic heart disease (IHD) and angina pectoris – more rarely than  LIS-1 patients. ACS was the first manifestation of IHD in 64% of LIS-3 register patients and 31.4% of LIS-1 register patients. Hospital lethality was 15.2% in LIS-1 register and 19.4% in LIS-3 register (p>0.05). Hospital lethality increased in elderly patients in both  registers. Atrial fibrillation increased hospital lethality risk in LIS-3 register and long-term mortality risk in LIS-1 register. History of arterial hypertension and angina pectoris re duced hospital lethality risk in LIS-3 register. In LIS-1 register neither of these factors was significant, but left ventricular hypertrophy reduced hospital mortality risk.

Conclusion. LIS-1 and LIS-3 patients were comparable in many factors, bud differed in history of IHD (31.4% in LIS-1 register, 64% in LIS-1 register) and angina pectoris. Factors associated with hospital mortality differed in the two registries.

About the Authors

S. Yu. Martsevich
State Research Centre for Preventive Medicine
Russian Federation

Sergey Yu. Martsevich – MD, PhD, Professor, Head of Department of Preventive Pharmacotherapy.

Petroverigsky per. 10,  Moscow, 101990



Y. V. Semenova
State Research Centre for Preventive Medicine
Russian Federation

Yulia V. Semenova – MD, Fellow.

Petroverigsky per. 10,  Moscow, 101990



N. P. Kutishenko
State Research Centre for Preventive Medicine
Russian Federation

Kutishenko N. Petrovna – MD, PhD, Head of Laboratory of Pharmacoeconomic Studies, Department of Preventive Pharmacotherapy.

Petroverigsky per. 10,  Moscow, 101990



M. L. Ginzburg
Lyubertsy District Hospital №2
Russian Federation

Moisei L. Ginzburg – MD, PhD, Head of Cardiology Department.

Oktyabr’skiy prospect 338, Moscow  Region, Lyubertsy, 140006



A. V. Zagrebelnyy
State Research Centre for Preventive Medicine
Russian Federation

Alexandr V. Zagrebelnyy – MD, PhD, Senior Researcher, Department of Preventive Pharmacotherapy.

Petroverigsky per. 10,  Moscow, 101990



A. V. Fokina
Lyubertsy District Hospital №2
Russian Federation

Anna V. Fokina – MD, Doctor of Cardiology Department.

Oktyabr’skiy prospect 338, Moscow  Region, Lyubertsy, 140006



E. V. Daniels
Lyubertsy District Hospital №2
Russian Federation

Elena V. Daniels – MD, Doctor of Cardiology Department.

Oktyabr’skiy prospect 338, Moscow  Region, Lyubertsy, 140006



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For citation:


Martsevich S.Y., Semenova Y.V., Kutishenko N.P., Ginzburg M.L., Zagrebelnyy A.V., Fokina A.V., Daniels E.V. LIS-3 REGISTER OF THE ACUTE CORONARY SYNDROME: WHAT HAS CHANGED IN A "PORTRAIT" OF A PATIENT AND SHORT-TERM OUTCOMES OF THE DISEASE COMPARED TO LIS-1 REGISTER. Rational Pharmacotherapy in Cardiology. 2017;13(1):63-68. (In Russ.) https://doi.org/10.20996/1819-6446-2017-13-1-63-68

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