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RESULTS OF HOSPITAL USE OF RECOMBINANT NON-IMMUNOGENIC STAPHYLOKINASE IN PATIENTS WITH ST-ELEVATED MYOCARDIAL INFARCTION

https://doi.org/10.20996/1819-6446-2017-13-1-51-54

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Abstract

Aim. To assess effectiveness and safety of the hospital use of recombinant non-immunogenic staphylokinase in patients with acute  ST-elevated myocardial infarction (STEMI).

Material and methods. Recombinant non-immunogenic staphylokinase was administered during in-hospital stage of treatment of 93 patients with acute STEMI, followed by clinical and electrocardiographic assessment and angiographic verification of the degree of blood flow in the infarct-related coronary  artery. Hemorrhagic complications, allergic reactions, and hospital mortality were also considered.

Results. When monitoring electrocardiogram after 90 minutes from the first bolus of recombinant non-immunogenic staphylokinase, the decrease of ST segment by 50% to the isoline was found in 93.5% of patients. Intracranial and extra brain major and small bleedings were not observed, as well as allergic reactions. In the group of patients who underwent coronary  angiography (n=15), antegrade blood flow TIMI 3 was visualized in 100% of cases. Hospital mortality was 6%.

Conclusion. Modern thrombolytic drug of recombinant non-immunogenic staphylokinase demonstrated high effectiveness in recovery of blood flow in the infarct-related coronary  artery,  hemorrhagic safety,  and easy to use in the bolus administration.

About the Author

V. B. Kostogryz
Institute of Emergency and Reconstructive Surgery
Russian Federation

Valeriy B. Kostogryz – MD, Cardiologist, Department of Emergency Cardiology and Thrombolysis.

Leninsky prosp. 47,  Donetsk, 83045

Ukraine



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For citation:


Kostogryz V.B. RESULTS OF HOSPITAL USE OF RECOMBINANT NON-IMMUNOGENIC STAPHYLOKINASE IN PATIENTS WITH ST-ELEVATED MYOCARDIAL INFARCTION. Rational Pharmacotherapy in Cardiology. 2017;13(1):51-54. (In Russ.) https://doi.org/10.20996/1819-6446-2017-13-1-51-54

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ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)