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EFFICIENCY OF INFLUENZA VACCINATION IN PATIENTS WITH CIRCULATORY SYSTEM DISEASES UNDER DISPENSARY OBSERVATION IN OUTPATIENT CLINICS: PROSPECTIVE FOLLOW-UP MONITORING DATA

https://doi.org/10.20996/1819-6446-2016-12-6-703-710

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Abstract

Aim. To estimate an efficiency of influenza vaccination in patients with circulatory system diseases diseases (CSD) under 3-year follow-up in outpatient clinics.

Methods. The efficiency of influenza vaccination was investigated in CSD patients followed up at 2Ivanovo outpatient clinics and 2Saratov ones. The investigation enrolled 817 people, including 367 patients who consented to Grippol Plus influenza vaccination and 450 who refused.

Results. During 36-month follow-up after being included in the study the vaccinated group showed a significantly fewer influenza and acute respiratory viral infections than the non-vaccinated group (28 and 442; р<0.0001). The vaccinated group had fewer CSD worsening cases per patient (p=0.04) and CSD-associated hospitalization rates (p=0.006) than the non-vaccinated group. In the vaccinated group, the total number of cases of cerebral stroke, myocardial infarction, deaths from cardiovascular diseases (CVD) was significantly less (17) compared with non-vaccinated (38), р=0.03. The risk of infectious diseases and acute cardiovascular event (myocardial infarction, stroke, death from CVD) was significantly lower in the group of vaccinated patients: by 36% (p=0.001) and by 59% (p=0.008), respectively.

Conclusion. Influenza vaccination, as an essential component of complex medical prevention, leads to reduction in incidence of infectious diseases and of CSD worsening including myocardial infarction, stroke, and death from CVD in patients under 3-year monitoring in outpatient clinics

About the Authors

S. A. Boytsov
State Research Center for Preventive Medicine
Russian Federation
Sergey A. Boytsov – MD, PhD, Professor, Corresponding Member of the Russian Academy of Sciences, Head of Department of Clinical Cardiology and Molecular Genetics, Director of State Research Center for Preventive Medicine


M. M. Loukianov
State Research Center for Preventive Medicine
Russian Federation

Michail M. Loukianov – MD, PhD, Leading Researcher, Department of Clinical Cardiology and Molecular Genetics,StateResearchCenterfor Preventive Medicine. 

Petroverigsky per., 10, Moscow, 101990



E. V. Platonova
State Research Center for Preventive Medicine
Russian Federation
Elena V. Platonova – MD, Researcher, Laboratory of Application of Outpatient Diagnostic Methods in the Prevention of Chronic Non-Communicable Diseases


V. M. Gorbunov
State Research Center for Preventive Medicine
Russian Federation
Vladimir M. Gorbunov - MD, PhD, Professor, Head of Laboratory of Application Outpatient Diagnostic Methods in the Prevention of Chronic Non-Communicable Diseases


S. V. Romanchuk
Ivanovo Regional Cardiology Clinic
Russian Federation

Svetlana V. Romanchuk - MD, PhD, Deputy Head of the Government of the Ivanovo Region, Director of the Health Department of the Ivanovo Region 



O. A. Nazarova
Ivanovo Regional Cardiology Clinic
Russian Federation
Olga A. Nazarova - MD, PhD, Professor, Head of Chair of Therapy and General Practice, Institute of Postgraduate Education


O. A. Belova
Ivanovo Regional Cardiology Clinic
Russian Federation

Olga A. Belova - MD, Medical Director



E. A. Kravtsova
Ivanovo Regional Cardiology Clinic
Russian Federation
Ekaterina A Kravtsova – MD, Cardiologist


P. Ya. Dovgalevsky
Saratov State Medical University named after V.I. Razumovsky
Russian Federation
Pavel Ya. Dovgalevsky - MD, PhD, Professor, Director of Saratov Research Institute of Cardiology


N. V. Furman
Saratov State Medical University named after V.I. Razumovsky
Russian Federation
Nikolai V. Furman - MD, PhD, Head of Department of Emergency Cardiology, Saratov Research Institute of Cardiology


A. A. Mironova
Saratov State Medical University named after V.I. Razumovsky
Russian Federation
Alexandra A. Mironova – MD, Junior Researcher, Department of Emergency Cardiology, Saratov Research Institute of Cardiology


P. V. Dolotovskaya
Saratov State Medical University named after V.I. Razumovsky
Russian Federation
Polina V. Dolotovskaya - MD, PhD, Researcher, Department of Emergency Cardiology, Saratov Research Institute of Cardiology


A. V. Nekrasov
State Research Center "Institute of Immunology", Federal Biomedical Agency of Russia
Russian Federation
Arkady V. Nekrasov - MD, PhD, Professor, Head of Laboratory of Synthetic Antigens


N. G. Puchkova
State Research Center "Institute of Immunology", Federal Biomedical Agency of Russia
Russian Federation
Natalia G. Puchkova - PhD in Chemistry, Leading Researcher, Laboratory of Synthetic Antigens


M. A. Abramova
State Research Center "Institute of Immunology", Federal Biomedical Agency of Russia
Russian Federation
Marina A. Abramova – PhD in Biology, Senior Researcher, Laboratory of Synthetic Antigens


E. N. Belova
State Research Center for Preventive Medicine
Russian Federation
Ekaterina N. Belova - programmer, Laboratory of Biostatistics


V. G. Klyashtorny
State Research Center for Preventive Medicine
Russian Federation
Vladislav G. Klyashtorny - PhD in Biology, Researcher, Laboratory of Biostatistics


A. D. Deev
State Research Center for Preventive Medicine
Russian Federation
Alexander D. Deev – PhD in Mathematics and Physics, Head of Laboratory of Biostatistics


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For citation:


Boytsov S.A., Loukianov M.M., Platonova E.V., Gorbunov V.M., Romanchuk S.V., Nazarova O.A., Belova O.A., Kravtsova E.A., Dovgalevsky P.Y., Furman N.V., Mironova A.A., Dolotovskaya P.V., Nekrasov A.V., Puchkova N.G., Abramova M.A., Belova E.N., Klyashtorny V.G., Deev A.D. EFFICIENCY OF INFLUENZA VACCINATION IN PATIENTS WITH CIRCULATORY SYSTEM DISEASES UNDER DISPENSARY OBSERVATION IN OUTPATIENT CLINICS: PROSPECTIVE FOLLOW-UP MONITORING DATA. Rational Pharmacotherapy in Cardiology. 2016;12(6):703-710. (In Russ.) https://doi.org/10.20996/1819-6446-2016-12-6-703-710

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