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ANNUAL FORECAST IN PATIENTS WITH ACUTE ISCHEMIC STROKE: ROLE OF PATHOLOGICAL ANKLE-BRACHIAL INDEX

https://doi.org/10.20996/1819-6446-2016-12-6-638-644

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Abstract

Aim. To study the factors associated with a poor annual prognosis in patients with acute stroke and prognostic role of pathological ankle-brachial index (ABI).

Material and methods. The study included 345 patients (age 63.6±7.8 years, 181 males and 164 females) with ischemic stroke that were observed for 1 year. All patients were divided into 2 groups: Group 1 included patients with favorable annual outcome of stroke; Group 2 included patients that during a year had any clinical events including death. All patients underwent a standard neurological and instrumental examination including assessment of peripheral arteries status by sphygmomanometry.

Results. Both groups did not differ by age and sex. The frequency of unfavorable outcomes (death, re-stroke, cardiovascular events) 1 year after ischemic stroke was 29.5%. Chronic heart failure, atrial fibrillation, previous cardiovascular events, presence of peripheral atherosclerosis, overweight were identified most commonly in Group 2. Patients of Group 2 initially had a rough neurological deficit. The pathological ABI was detected in 70.7% of patients in Group 2 vs 33.8% of patients in Group 1 (p=0.000001). A strong relationship of pathological ABI with a poor outcome of stroke was found by regression analysis.

Conclusions. Detection of pathological ABI in patients with ischemic stroke makes it possible to reveal peripheral atherosclerosis and to carry out the targeted preventive measures in these patients. Risk stratification can contribute to more individual and effective secondary prevention in patients with cerebrovascular disease. 

About the Authors

A. N. Sumin
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Alexey N. Sumin – MD, PhD., Head of Department of Multifocal Atherosclerosis ией нейрососудистой патологии отдела МФА


J. A. Kolmykova
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation

Juliya A. Kolmykova – Junior Researcher, Laboratory of Neurovascular Disease, Department of Multifocal Atherosclerosis. 

Sosnovii bul., 6, Kemerovo, 650002



I. N. Kukhareva
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Irina N. Kukhareva – Researcher, Laboratory of Neurovascular Disease, Department of Multifocal Atherosclerosis


M. V. Ott
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Margarita V. Ott – Junior Researcher, Laboratory of Neurovascular Diseases, Department of Multifocal Atherosclerosis


N. I. Vodopyanova
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Nina I. Vodopyanova – Junior Researcher, Laboratory of Neurovascular Disease Department of Multifocal Atherosclerosis


A. A. Morkvenas
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Anna A. Morkvenas – Junior Researcher, Laboratory of Neurovascular Disease Department of Multifocal Atherosclerosis


O. A. Trubnikova
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Olga A. Trubnikova – MD, PhD., Head of Laboratory of Neurovascular Disease, Department of Multifocal Atherosclerosis


A. V. Kovalenko
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Andrey V. Kovalenko – MD, PhD., Professor, Senior Researcher, Laboratory of Neurovascular Disease, Department of Multifocal Atherosclerosis


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For citation:


Sumin A.N., Kolmykova J.A., Kukhareva I.N., Ott M.V., Vodopyanova N.I., Morkvenas A.A., Trubnikova O.A., Kovalenko A.V. ANNUAL FORECAST IN PATIENTS WITH ACUTE ISCHEMIC STROKE: ROLE OF PATHOLOGICAL ANKLE-BRACHIAL INDEX. Rational Pharmacotherapy in Cardiology. 2016;12(6):638-644. (In Russ.) https://doi.org/10.20996/1819-6446-2016-12-6-638-644

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