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Antiarrhythmic Drugs Use in Elderly Patients. Vaughan Williams Class III and IV Drugs

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The effectiveness of antiarrhythmic drugs in the elderly is similar to that in younger patients. However data for «the very elderly» are lacking. Elderly patients are more vulnerable to adverse drug reactions (ADRs) because of age-related changes of pharmacokinetics, co-morbidity and drug interactions. Аmioadarone is not considered as the drug of choice in elderly patients because of the high risk of serious ADRs. Other class III drugs should be prescribed to the elderly with great caution under close monitoring of the treatment. Diltiazem and verapamil should not be used in elderly patients with NYHA class III-IV heart failure and should not be combined with β-blockers.

About the Authors

E. A. Ushkalova
People's Friendship University of Russia. Miklukho-Maklaya ul. 6, Moscow, 117198 Russia
Russian Federation

MD, PhD, Professor of Chair of the General and Clinical Pharmacology, People's Friendship University of Russia

S. K. Zyryanov
People's Friendship University of Russia. Miklukho-Maklaya ul. 6, Moscow, 117198 Russia
Russian Federation

MD, PhD, Head of Chair of the General and Clinical Pharmacology, People's Friendship University of Russia

K. E. Zatolochina
People's Friendship University of Russia. Miklukho-Maklaya ul. 6, Moscow, 117198 Russia
Russian Federation

MD, PhD, Teaching Assistant of Chair of the General and Clinical Pharmacology, People's Friendship University of Russia

A. P. Pereverzev
People's Friendship University of Russia. Miklukho-Maklaya ul. 6, Moscow, 117198 Russia
Russian Federation

MD, PhD, Associate Professor of Chair of the General and Clinical Pharmacology, People's Friendship University of Russia

N. A. Chukhareva
Scientific Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov. Academika Oparina ul. 4, Moscow, 117997 Russia
Russian Federation

MD, Junior Researcher, Internal Medicine Department, Scientific Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov


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For citations:

Ushkalova E.A., Zyryanov S.K., Zatolochina K.E., Pereverzev A.P., Chukhareva N.A. Antiarrhythmic Drugs Use in Elderly Patients. Vaughan Williams Class III and IV Drugs. Rational Pharmacotherapy in Cardiology. 2016;12(5):603-609. (In Russ.)

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