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Rational Pharmacotherapy in Cardiology

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Pathogenic Mechanisms of Atrial Fibrillation in Obesity

https://doi.org/10.20996/1819-6446-2016-12-5-582-589

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Abstract

Atrial fibrillation (AF) is one of the most common arrhythmias. It reduces quality of life and its duration due to thromboembolic complications. Obesity contributes to the structural and electrical remodeling of atrial myocardium. This leads to occurrence of ectopic foci in the mouths of the pulmonary veins and the disruption of normal electrical conduction in the atria. Systemic inflammation, myocardial fibrosis, cardiomyocyte overload by Na+ and Ca2+ ions, accumulation in the cells of unoxidized metabolic products, imbalance of the autonomic regulation are considered as the main mechanisms of arrhythmogenic substrate formation. Hypertension, insulin resistance, and obstructive sleep apnea, associated with obesity, increase the risk of development and progression of the arrhythmia. Study of pathogenetic mechanisms of AF in obesity is necessary to develop new strategies for its prevention and the creation of more effective methods of treatment of these patients.

About the Authors

O. M. Drapkina
State Research Center for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia
Russian Federation

MD, PhD, Professor, Deputy Director for Research and Clinical Work, State Research Center for Preventive Medicine



M. V. Nikolaeva
I.M. Sechenov First Moscow State Medical University. Trubetskaya ul. 8-2, Moscow, 119991 Russia
Russian Federation

5th Year Student, I.M. Sechenov First Moscow State Medical University



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For citation:


Drapkina O.M., Nikolaeva M.V. Pathogenic Mechanisms of Atrial Fibrillation in Obesity. Rational Pharmacotherapy in Cardiology. 2016;12(5):582-589. (In Russ.) https://doi.org/10.20996/1819-6446-2016-12-5-582-589

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