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Antiarrhythmic drugs use in elderly patients. Vaughan Williams class I and II drugs

https://doi.org/10.20996/1819-6446-2016-12-4-471-478

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Abstract

Use of class I antiarrhythmic drugs in the elderly is limited by their adverse drug reactions (ADRs), proarrhythmic effect (I A и I C) and high risk of drug interactions. Disopyramide use should be avoided due to its strong anticholinergic properties associated with the risk of cognitive and physical disorders and falls in the “very elderly” patients. Available data suggest that elderly patients do not have significant limitations for beta-blockers use. However to determine beta-blockers with the best benefit/risk ratio in elderly patients with co-morbidity further clinical trials are needed.

About the Authors

E. A. Ushkalova
People's Friendship University of Russia
Russian Federation
Miklukho-Maklaya ul. 6, Moscow, 117198


S. K. Zyryanov
People's Friendship University of Russia
Russian Federation
Miklukho-Maklaya ul. 6, Moscow, 117198


K. E. Zatolochina
People's Friendship University of Russia
Russian Federation
Miklukho-Maklaya ul. 6, Moscow, 117198


A. P. Pereverzev
People's Friendship University of Russia
Russian Federation
Miklukho-Maklaya ul. 6, Moscow, 117198


N. A. Chukhareva
Scientific Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov
Russian Federation
Oparina ul. 4, Moscow, 117997


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For citation:


Ushkalova E.A., Zyryanov S.K., Zatolochina K.E., Pereverzev A.P., Chukhareva N.A. Antiarrhythmic drugs use in elderly patients. Vaughan Williams class I and II drugs. Rational Pharmacotherapy in Cardiology. 2016;12(4):471-478. (In Russ.) https://doi.org/10.20996/1819-6446-2016-12-4-471-478

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