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EFFECT OF GENDER DIFFERENCES ON THE EFFICACY AND SAFETY OF REPERFUSION THERAPY OF ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (DATA OF RETROSPECTIVE SINGLE-CENTER STUDY – HOSPITAL PERIOD)

https://doi.org/10.20996/1819-6446-2016-12-3-296-301

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Abstract

Gender differences can significantly affect mortality in ST-segment elevation myocardial infarction (STEMI) in real practice. Aim. To evaluate the effect of gender on mortality in STEMI. Material and methods. Outcomes of in-hospital stage of treatment of 553 men (67.7%) and 263 women (32.3%) were analyzed in single-center retrospective study. Primary percutaneous coronary intervention (pPCI) and pharmacoinvasive strategy (PIS) were used in 160 (60.8%) and 103 (39.2%) women, respectively, as well as in 295 (53.3%) and 258 (46.7%) men, respectively. Patients with time ″primary medical contact (PMC) – balloon″ less than 60 min and ″symptom - PMC″ more than 6 hours were excluded. The majority of patients were in a time interval ″PMC - balloon″ about 120 minutes. Results. Mortality in women was significantly higher than this in men regardless of the reperfusion strategy – 15.3% in whole (18.1% at pPCI and 10.9% at PIS), and 3.1% in whole (5.1% at pPCI and 0.8% at FIS), respectively (p<0.001). The probability of lethal outcome in women was 4 times higher than this in men (odds ratio 4.4; 95% confidence interval 2.7-7.1). Conclusion. Clinical characteristics of the patients due to gender differences make a significant contribution to the course of STEMI. Women more often have severe complications and a worse in-hospital prognosis.

About the Authors

D. B. Nemik
Krasnoyarsk State Medical University named after Professor. V.F. Voino-Yasenetsky. Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022 Russia Krasnoyarsk Regional Clinical Hospital. Partizana Zheleznyaka ul. 3a, Krasnoyarsk, 660022 Russia
Russian Federation


G. V. Matyushin
Krasnoyarsk State Medical University named after Professor. V.F. Voino-Yasenetsky. Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022 Russia
Russian Federation


A. V. Protopopov
Krasnoyarsk State Medical University named after Professor. V.F. Voino-Yasenetsky. Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022 Russia Krasnoyarsk Regional Clinical Hospital. Partizana Zheleznyaka ul. 3a, Krasnoyarsk, 660022 Russia
Russian Federation


A. V. Shulmin
Krasnoyarsk State Medical University named after Professor. V.F. Voino-Yasenetsky. Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022 Russia
Russian Federation


S. A. Ustyugov
Krasnoyarsk Regional Clinical Hospital. Partizana Zheleznyaka ul. 3a, Krasnoyarsk, 660022 Russia
Russian Federation


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For citation:


Nemik D.B., Matyushin G.V., Protopopov A.V., Shulmin A.V., Ustyugov S.A. EFFECT OF GENDER DIFFERENCES ON THE EFFICACY AND SAFETY OF REPERFUSION THERAPY OF ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (DATA OF RETROSPECTIVE SINGLE-CENTER STUDY – HOSPITAL PERIOD). Rational Pharmacotherapy in Cardiology. 2016;12(3):296-301. https://doi.org/10.20996/1819-6446-2016-12-3-296-301

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