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CORRELATIONS OF DIFFERENT STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF ARTERIAL WALL WITH TRADITIONAL CARDIOVASCULAR RISK FACTORS IN HEALTHY PEOPLE OF DIFFERENT AGE. PART 2

https://doi.org/10.20996/1819-6446-2016-12-3-244-252

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Abstract

Detection of principal subclinical arterial wall lesions is one of the most important aspects of effective cardiovascular disease (CVD) primary prevention. Such lesions include: arterial wall thickening, increased rigidity, endothelial dysfunction development. However, the role of traditional CVD risk factors in the development of individual arterial wall lesions in CVD-free people is understudied. This is particularly so with people of older age. Aim. To study the role of traditional CVD risk factors in development of arterial wall lesions in relatively healthy individuals of different age. Material and methods. We have examined a total of 303 people aged 25-91 years, with no signs of CVD and other chronic diseases and without any regular medical treatment. Anthropometric parameters, blood pressure, fasting plasma glucose, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides levels were detected in all the patients. Measurement of pulse wave velocity was conducted using SphygmoCor device (AtCorMedical,Australia). Carotid ultrasound to measure intima-media thickness and number of atherosclerotic plaques was conducted using linear transducer with ultra-high resolution 17-5 MHz (PHILIPS iU22, the Netherlands) in the B-mode. Endothelium-dependent vasodilation was assessed by the reactive hyperemia test. Results. Multivariate linear regression analysis has revealed fasting hyperglycemia and increased systolic blood pressure to be to a greater degree associated with arterial wall state in both age groups. According to the results of multivariate logistic regression analysis a relationship between risk factors and arterial wall parameters is stronger in the younger group as compared with the older one. Conclusion. Systolic blood pressure and fasting hyperglycemia must be the main targets of CVD primary prevention in older age group, while in younger age group other traditional risk factors must be taken into account as well.

About the Authors

I. D. Strazhesko
State Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia
Russian Federation
MD, PhD, Leading Researcher of the Department of Investigation of Ageing and Age-associated Diseases Prevention, State Research Center for Preventive Medicine (SRC PM)


O. N. Tkacheva
State Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia Russian Gerontology Research Center, Russian National Research Medical University named after Y.I. Pirogov. Pervaya Leonova ul. 16, Moscow, 129226 Russia
Russian Federation
MD, PhD, Professor, Head of the Department of Investigation of Ageing and Age-associated Diseases Prevention; Director of the Russian Gerontology Research Center, Russian National Research Medical University named after Y.I. Pirogov


D. U. Akasheva
State Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia
Russian Federation
MD, PhD, Leading Researcher of the of the Department of Investigation of Ageing and Age-associated Diseases Prevention, SRC PM


E. V. Dudinskaya
State Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia Russian Gerontology Research Center, Russian National Research Medical University named after Y.I. Pirogov. Pervaya Leonova ul. 16, Moscow, 129226 Russia
Russian Federation
MD, PhD, Leading Researcher of the of the Department of Investigation of Ageing and Age-associated Diseases Prevention


M. V. Agaltsov
State Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia
Russian Federation
MD, PhD, Senior Researcher of the of the Department of Investigation of Ageing and Age-associated Diseases Prevention


A. S. Kruglikova
State Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia
Russian Federation
MD, Junior Researcher of the of the Department of Investigation of Ageing and Age-associated Diseases Prevention


N. V. Brailova
State Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia
Russian Federation
MD, Junior Researcher of the of the Department of Investigation of Ageing and Age-associated Diseases Prevention


V. S. Pykhtina
State Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia
Russian Federation
MD, Junior Researcher of the of the Department of Investigation of Ageing and Age-associated Diseases Prevention


E. V. Plokhova
State Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia
Russian Federation
MD, PhD, Researcher of the of the Department of Investigation of Ageing and Age-associated Diseases Prevention


N. V. Sharashkina
State Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia Russian Gerontology Research Center, Russian National Research Medical University named after Y.I. Pirogov. Pervaya Leonova ul. 16, Moscow, 129226 Russia
Russian Federation
MD, PhD, Senior Researcher of the of the Department of Investigation of Ageing and Age-associated Diseases Prevention


O. Yu. Isaykina
State Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia
Russian Federation
MD, PhD, Senior Researcher of the Department of Primary Prevention of Chronic Non-infectious Diseases, SRC PM


V. A. Vygodin
State Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia
Russian Federation
Senior Researcher of the Laboratory of Biostatistics, SRC PM


S. A. Boytsov
State Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia
Russian Federation
MD, PhD, Professor, Head of the Department of Cardiology and Molecular Genetics, SRC PM, Director of the SRC PM


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For citation:


Strazhesko I.D., Tkacheva O.N., Akasheva D.U., Dudinskaya E.V., Agaltsov M.V., Kruglikova A.S., Brailova N.V., Pykhtina V.S., Plokhova E.V., Sharashkina N.V., Isaykina O.Y., Vygodin V.A., Boytsov S.A. CORRELATIONS OF DIFFERENT STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF ARTERIAL WALL WITH TRADITIONAL CARDIOVASCULAR RISK FACTORS IN HEALTHY PEOPLE OF DIFFERENT AGE. PART 2. Rational Pharmacotherapy in Cardiology. 2016;12(3):244-252. https://doi.org/10.20996/1819-6446-2016-12-3-244-252

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ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)