Rational Pharmacotherapy in Cardiology

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Aim. To study the association of depression with a high-sensitivity C-reactive protein (hsCRP) level, taking into account the main risk factors and noncommunicable diseases in Russia residents.
Material and methods. The data of ESSE-RF multicenter study (a representative sample of the unorganized male and female population aged 25-64 years from 8 regions surveyed in 2012-2014) were used in the work. A total 11884 people were involved into the study including 35.9% men. The examination included a survey on the standard questionnaire containing data on disease history, etc. The level of depression was assessed by the validated in Russian Hospital Anxiety and Depression Scale (HADS, 1983). hsCRP level was determined in all patients.
Results. The continuing association between elevated levels of depression (HADS-D ≥8+) and high level of hsCRP ≥3.0 mg/l (odds ratio [OR] 1.15; 95% confidence interval [CI] 1.03-1.27; p=0.009) was found in the multivariate model, after adjustment for sex, age, education, and risk factors. Reducing of the relationship of elevated levels of depression with a high level of hsCRP (OR 1.11; 95% CI 1.00-1.24; p=0.048) was found with the additional introduction of diseases in the model. This relationship was reduced to not statistically significant level (OR 1.08; 95% CI 0.98-1.20; p=0.134) in the full model adjusted for regions.
Conclusion. The reduced association of depression with hsCRP ajusted for aggregate risk factors was found in the study. This suggests about multifactor affecting on this relationship.

About the Authors

S. E. Evstifeeva
State Research Center for Preventive Medicine, Moscow
Russian Federation

S. A. Shalnova
State Research Center for Preventive Medicine, Moscow
Russian Federation

A. D. Deev
State Research Center for Preventive Medicine, Moscow
Russian Federation

V. A. Metelskaya
State Research Center for Preventive Medicine, Moscow
Russian Federation

G. V. Artamonova
Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo
Russian Federation

O. A. Belova
Ivanovo Municipal Cardiology Hospital, Ivanovo
Russian Federation

J. V. Zhernakova
Tyumen State Medical Academy, Tyumen
Russian Federation

A. Yu. Efanov
Russian Cardiology Research and Production Complex, Moscow
Russian Federation

A. O. Konradi
North-West Federal Almazov Medical Research Centre, St. Petersburg
Russian Federation

N. V. Kulakova
State Pacific Medical University, Vladivostok
Russian Federation

O. P. Rotar
North-West Federal Almazov Medical Research Centre, St. Petersburg
Russian Federation

G. V. Tolparov
North Ossetia State Medical Academy, Vladikavkaz
Russian Federation

I. A. Trubacheva
Research Institute for Cardiology, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation

A. A. Shabunova
Institute of Socio-Economic Development of Territories, Russia Academy of Ssiences, Vologda
Russian Federation

S. A. Boytsov
State Research Center for Preventive Medicine, Moscow
Russian Federation


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For citation:

Evstifeeva S.E., Shalnova S.A., Deev A.D., Metelskaya V.A., Artamonova G.V., Belova O.A., Zhernakova J.V., Efanov A.Y., Konradi A.O., Kulakova N.V., Rotar O.P., Tolparov G.V., Trubacheva I.A., Shabunova A.A., Boytsov S.A. THE ASSOCIATION OF DEPRESSION WITH C-REACTIVE PROTEIN (THE DATA OF ESSE-RF EPIDEMIOLOGICAL STUDY). Rational Pharmacotherapy in Cardiology. 2016;12(2):129-137. (In Russ.)

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