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CORRELATIONS OF DIFFERENT STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF ARTERIAL WALL WITH TRADITIONAL CARDIOVASCULAR RISK FACTORS IN HEALTHY PEOPLE OF DIFFERENT AGE. PART 1

https://doi.org/10.20996/1819-6446-2016-12-2-118-128

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Abstract

Arterial wall status is determined by several characteristics, the main of them are as follows: pulse wave velocity (PWV), carotid arteries intima-media thickness (IMT), the presence of atherosclerotic plaques, endothelium-dependent vasodilation (EDVD). When these parameters change, the risk for cardiovascular disease (CVD) grows. The nature of relationship between these indices in people without CVD clinical signs is understudied, especially in those of older age.
Aim. To estimate correlations between different parameters of arterial wall in patients of different age without CVD.
Material and methods. A total of 303 people aged 25-91 years without any manifestations of CVD or other chronic diseases and without regular medical treatment were examined. PWV estimation, carotid ultrasound with IMT measurement and atherosclerotic plaques amount calculation and EDVD estimation using reactive hyperemia test were performed. Results. Patients without CVD clinical signs rather often reveal arterial wall lesions already in the younger age group (mean age 40.9±8.7): reduced EDVD – in 26% of the cases, the presence of atherosclerotic plaques – in 22%, increased PWV – in 15%, increased IMT – in 8%. The prevalence of arterial wall alterations in the older age group (mean age 61.19±8.5) increase many-fold. All arterial wall parameters correlate with age. The stronger correlation was revealed between IMT and the amount of atherosclerotic plaques: r=0.46 (р<0.001) in the younger group and r=0.47 (р<0.001) in the older one. We didn’t find any relationship between PWV and EDVD in the younger group and between PWV and the amount of atherosclerotic plaques in the older one. Thickened carotid intima-media increases the risk of arterial stiffness by 2.3 times.
Conclusion. Estimation of the state of arterial wall in people of young age without CVD allows detecting individuals who require active CVD prevention. Increased stiffness of arterial wall and the development of subclinical atherosclerosis represent different phenotypes of alterations.

About the Authors

I. D. Strazhesko
State Research Centre for Preventive Medicine, Moscow
Russian Federation

Irina D. Strazhesko – MD, PhD, Leading Researcher of the Department of Investigation of Ageing and Age-associated Diseases Prevention, State Research Center for Preventive Medicine (SRC PM) 



O. N. Tkacheva
State Research Centre for Preventive Medicine, Moscow; Russian Gerontology Research Center, Russian National Research Medical University named after Y.I. Pirogov, Moscow
Russian Federation

Olga N. Tkacheva – MD, PhD, Professor, Head of the Department of Investigation of Ageing and Age-associated Diseases Prevention; Director of the Russian Gerontology Research Center, Russian National Research Medical University named after Y.I. Pirogov



D. U. Akasheva
State Research Centre for Preventive Medicine, Moscow
Russian Federation

 Dariga U. Akasheva – MD, PhD, Leading Researcher of the of the Department of Investigation of Ageing and Age-associated Diseases Prevention, SRC PM



E. V. Dudinskaya
State Research Centre for Preventive Medicine, Moscow
Russian Federation

Ekaterina N. Dudinskaya – MD, PhD, Leading Researcher of the Department of Investigation of Ageing and Age-associated Diseases Prevention, SRC PM 



M. V. Agaltsov
State Research Centre for Preventive Medicine, Moscow
Russian Federation

Michail V. Agaltsov – MD, PhD, Senior Researcher of the Department of Investigation of Ageing and Age-associated Diseases Prevention, SRC PM



A. S. Kruglikova
State Research Centre for Preventive Medicine, Moscow
Russian Federation

Anna S. Kruglikova – MD, Junior Researcher of the Department of Investigation of Ageing and Age-associated Diseases Prevention, SRC PM



N. V. Brailova
State Research Centre for Preventive Medicine, Moscow
Russian Federation

Natalya V. Brailova – MD, Junior Researcher of the Department of Investigation of Ageing and Age-associated Diseases Prevention, SRC PM



V. S. Pykhtina
State Research Centre for Preventive Medicine, Moscow
Russian Federation

Valentina S. Pykhtina – MD, Junior Researcher of the Department of Investigation of Ageing and Age-associated Diseases Prevention, SRC PM



E. V. Plokhova
State Research Centre for Preventive Medicine, Moscow
Russian Federation

Ekaterina V. Plokhova – MD, PhD, Researcher of the Department of Investigation of Ageing and Age-associated Diseases Prevention, SRC PM



N. V. Sharashkina
State Research Centre for Preventive Medicine, Moscow
Russian Federation

Natalya V. Sharashkina – MD, PhD, Senior Researcher of the Department of Investigation of Ageing and Age-associated Diseases Prevention, SRC PM



O. Yu. Isaykina
State Research Centre for Preventive Medicine, Moscow
Russian Federation

Olesya Yu. Isaykina – MD, PhD, Senior Researcher of the Department of Primary Prevention of Chronic Non-infectious Diseases, SRC PM 



V. A. Vygodin
State Research Centre for Preventive Medicine, Moscow
Russian Federation

Vladimir A. Vygodin – Senior Researcher of the Laboratory of Biostatistics, SRC PM



S. A. Boytsov
State Research Centre for Preventive Medicine, Moscow
Russian Federation

Sergey A. Boytsov – MD, PhD, Professor, Head of the Department of Cardiology and Molecular Genetics, SRC PM, Director of the SRC PM



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For citation:


Strazhesko I.D., Tkacheva O.N., Akasheva D.U., Dudinskaya E.V., Agaltsov M.V., Kruglikova A.S., Brailova N.V., Pykhtina V.S., Plokhova E.V., Sharashkina N.V., Isaykina O.Y., Vygodin V.A., Boytsov S.A. CORRELATIONS OF DIFFERENT STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF ARTERIAL WALL WITH TRADITIONAL CARDIOVASCULAR RISK FACTORS IN HEALTHY PEOPLE OF DIFFERENT AGE. PART 1. Rational Pharmacotherapy in Cardiology. 2016;12(2):118-128. (In Russ.) https://doi.org/10.20996/1819-6446-2016-12-2-118-128

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