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Rational Pharmacotherapy in Cardiology

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HEART FAILURE, DIABETES, BETA-BLOCKERS AND RISK OF HYPOGLYCEMIA

https://doi.org/10.20996/1819-6446-2008-4-3-47-51

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Abstract

Aim. To evaluate an influence of carvedilol on risk of hypoglycemia in patients with diabetes type 2 (D2) and chronic heart failure (CHF) treated with angiotensin converting enzyme (ACE) inhibitors.

Material and methods. 13 patients (10 men, 3 women; aged 59,8±6,7 y.o.) with D2 and CHF caused by ischemic heart disease were included in the study. Before inclusion all patients were treated with ACE inhibitors and various beta-blockers (atenolol, metoprolol, bisoprolol). These beta-blockers were changed for carvedilol. Heart ultrasonography, blood pressure control, glycemia monitoring, HbA1c level determination were performed before, during and after carvedilol therapy.

Results. Carvedilol reduces frequency and duration of hypoglycaemia episodes. There were not episodes of severe hypoglycaemia during carvedilol therapy.

Conclusion. Carvedilol reduces risk of hypoglycemia when it is used in combination with ACE inhiditors in diabetic patients with CHF.

About the Authors

A. A. Aleksandrov
Endocrinology Research Center of Rosmedtechnology, Moscow
Russian Federation
Department of Cardiology


O. А. Shatskaya
Endocrinology Research Center of Rosmedtechnology, Moscow
Russian Federation
Department of Cardiology


S. S. Kuharenko
Endocrinology Research Center of Rosmedtechnology, Moscow
Russian Federation
Department of Cardiology


E. N. Drozdova
Endocrinology Research Center of Rosmedtechnology, Moscow
Russian Federation
Department of Cardiology


I. Z. Bondarenko
Endocrinology Research Center of Rosmedtechnology, Moscow
Russian Federation
Department of Cardiology


N. D. Tabidze
Endocrinology Research Center of Rosmedtechnology, Moscow
Russian Federation
Department of Cardiology


M. V. Shestakova
Endocrinology Research Center of Rosmedtechnology, Moscow
Russian Federation
Department of Cardiology


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For citation:


Aleksandrov A.A., Shatskaya O.А., Kuharenko S.S., Drozdova E.N., Bondarenko I.Z., Tabidze N.D., Shestakova M.V. HEART FAILURE, DIABETES, BETA-BLOCKERS AND RISK OF HYPOGLYCEMIA. Rational Pharmacotherapy in Cardiology. 2008;4(3):47-51. (In Russ.) https://doi.org/10.20996/1819-6446-2008-4-3-47-51

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ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)