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ACUTE CEREBROVASCULAR EVENTS IN PATIENTS WITH ARTERIAL HYPERTENSION: MOLECULAR GENETIC ASPECTS

https://doi.org/10.20996/1819-6446-2008-4-1-33-38

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Abstract

Aim. To study association between stroke and gene polymorphism of angeotensin converting enzyme (ACE), angeotensin II type 1 receptor (ATR1), apolipoprotein СIII (APO CIII), apoproteine Е (APO E), methylentetrahydrofolate reductase (MTHFR), fibrinogen (Fb), endothelial NO-synthase (NOS3) in arterial hypertension (HT).

Material and methods. Molecular genetic analysis by polymerase chain reaction was done in 41 patients with HT, who experienced first episode of acute disturbances of cerebral blood circulation (ADCBC).

Results. Stroke rate in patients with HT is associated with A1166C of ATR1 gene polymorphism, G-455A of Fb gene polymorphism and C677T of MTHFR gene polymorphism. The high risk markers are C-allele of ATR1 gene, -455А allele and AA genotype of Fb gene, 677T allele of MTHFR. The A-allele and genotype AA of ATR1 gene, G-445 allele of Fb gene, С677-allele and CC genotype of MTHFR gene play protective role against ADCBC in HT.

Conclusion. It is established an association between gene polymorphism of some molecules and ADCBC in HT.

About the Authors

M. A. Karpenko
Military-medical Academy named after S.M. Kirov, St.-Petersburg. Federal Center of Heart, Blood and Endocrinology named after V.A. Almazov, St.-Petersburg. St.-Petersburg State University, St.-Petersburg State Pediatric Medical Academy
Russian Federation


E. G. Shatskaya
Military-medical Academy named after S.M. Kirov, St.-Petersburg. Federal Center of Heart, Blood and Endocrinology named after V.A. Almazov, St.-Petersburg. St.-Petersburg State University, St.-Petersburg State Pediatric Medical Academy
Russian Federation


V. N. Solntsev
Military-medical Academy named after S.M. Kirov, St.-Petersburg. Federal Center of Heart, Blood and Endocrinology named after V.A. Almazov, St.-Petersburg. St.-Petersburg State University, St.-Petersburg State Pediatric Medical Academy
Russian Federation


M. A. Bogdanov
Military-medical Academy named after S.M. Kirov, St.-Petersburg. Federal Center of Heart, Blood and Endocrinology named after V.A. Almazov, St.-Petersburg. St.-Petersburg State University, St.-Petersburg State Pediatric Medical Academy
Russian Federation


V. I. Larionova
Military-medical Academy named after S.M. Kirov, St.-Petersburg. Federal Center of Heart, Blood and Endocrinology named after V.A. Almazov, St.-Petersburg. St.-Petersburg State University, St.-Petersburg State Pediatric Medical Academy
Russian Federation


References

1. Гусев Е.И., Скворцова В.И., Стаховская Л.В. Эпидемиология инсульта в России. Журн неврол психиатр им СС Корсакова 2003;(прил 8):4–9.

2. Скворцова В.И., Лимборская С.А., Сломинский П.А., и др. Полиморфизм гена ангиотензинпревращающего фермента у больных с ишемической болезнью головного мозга. Журн неврол психиатр им СС Корсакова 2001;(прил 3): 21–7.

3. Badenhop R.F., Wang X.L., Wilcken D.E. Angiotensin-converting enzyme genotype in children and coronary events in their grandparents. Circulation 1995;91(6):1655-8.

4. Badenhop RF, Wang XL, Wilcken DE. Association between an angiotensinogen microsatellite marker in children and coronary events in their grandparents. Circulation 1996;93:2092–6.

5. Моляка Ю.К., Петрук С.В., Кирьянов С.А. и др. Анализ ассоциации полиморфизма генов ангиотензинпревращающего фермента при ишемическом инсульте. Журн неврол психиатр им СС Корсакова 1998;98(6):35–7.

6. Скворцова В.И., Сломинский П.А., Кольцова Е.А., и др. Изучение роли миссенс-мутации (M235T) гена ангиотензинпревращающего фермента в развитии ишемической болезни мозга. Мол ген микробиол вирусол 2003;1:52-4.

7. Демуров Л.М., Чистяков Д.А., Чугунова Л.А. и др. Исследование полиморфизма типа вставка/делеция гена ангиотензинпревращающего фермента в норме и среди больных сахарным диабетом с сосудистыми осложнениями. Мол биол 1997;31(1):59–62.

8. Котовская Ю.В., Кобалава Ж.Д., Сергеева Т.С., и др. Полиморфизм генов ренин-ангиотензиновой системы и гена эндотелиальной NО- синтетазы и микрососудистые осложнения при сахарном диабе- те типа 2. Артериальная гипертензия 2002;8(3):86–96.

9. Araujo M.A., Goulart L.R., Cordeiro E.R., et al. Genotypic interactions of renin-angiotensin system genes in myocardial infarction. Int J Cardiol 2005;103(1):27-32.

10. Berge K.E., Bakken A., Bohn M. et al. A DNA polymorphism at the angiotensin II type 1 receptor (AT1R) locus and myocardial infarction. Clin Genet 1997;52:71–6.

11. Amant C., Hamon M., Banters G. et al. The angiotensin II type 1 receptor gene polymorphism is associated with coronary artery vasoconstriction. Am J Cardiol 1997;29:486–90.

12. Henskens L.H., Kroon A.A., van Boxtel M.P., et al. Associations of the angiotensin II type 1 receptor A1166C and the endothelial NO synthase G894T gene polymorphisms with silent subcortical white matter lesions in essential hypertension. Stroke 2005;36(9):1869-73.

13. Castellano M., Muiesan M.L., Beschi M. et al. Angiotensin II type 1 receptor A/C1166 polymorphism. Relationships with blood pressure and cardiovascular structure. Hypertension 1996;28:1076–80.

14. Zeng Q., Dammerman M., Takada Y. et al. An apolipoprotein CIII marker associated with hypertriglyceridemia in Caucasians also confers increased risk in a west Japanese population. Hum Genet 1995;95:371- 5.

15. Talmud P.J., Humphries S.E. Apolipoprotein C-III gene variation and dyslipidaemia. Curr Opin Lipidol 1997;8(3):154-8.

16. Shoulders C.C., Harry P.J., Lagrost L. et al. Variation at the apo AI/CIII/AIV gene complex is associated with eleveted plasma levels of Apo CIII. Atherosclerosis 1991;87:239-47.

17. Stengard J., Zerba K., Pekkanen J. et al. Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men. Circulation 1995;91:265-9.

18. Anstey K., Christensen H. Education, activity, health, blood pressure and apolipoprotein E as predictors of cognitive change in old age: a review. Gerontology 2000;46(3):163-77.

19. Corbo R., Scacchi R., Mureddu L. et al. Apolipoprotein B, apolipoprotein E and angiotensin-converting enzyme polymorphisms in 2 Italian populations at different risk for coronary artery disease and comparison of allele freguencies among European populations. Hum Biol 1999;71(6):933-45.

20. Cattaneo M. Hyperhomocysteinemia, atherosclerosis and thrombosis. Thromb Haemost 1999;81:165–76.

21. Wotherspoon F., Laight D., Shaw K., Cummings M. Homocysteine, endothelial dysfunction and oxidative stress in type 1 diabetes mellitus. Br J Diabetes Vasc Dis 2003;3(5):334–40.

22. Cappuccio F., Bell R., Perry I. et al. Homocysteine levels in men and women of different ethnic and cultural background living in England. Atherosclerosis 2002;164(1):95–102.

23. Tybjaeg-Hansen A., Agerholm-Larsen B., Humphries S.E., et al. A common mutation (G-455 A) in the -fibrinogen promoter is an independent predictor of plasma fibrinogen, but not of ischemic heart disease. A study of 9,127 individuals based on The Copenhagen City Heart Study. J Clin Invest 1997;99:3034-9.

24. Kessler C., Spitzer C., Stauske D., et al. The apolipoprotein E and -fibrinogen G/A –455 gene polymorphisms are associated with ischaemic stroke involving large-vessel disease. Arterioscler Thromb Vasc Biol 1997;17:2880–4.

25. Wang X.L., Sim A.S., Badenhop R.F. et al. A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nat Med 1996;2:41-5.

26. Tsukada T., Yokoyama K., Aral T. et al. Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans. Biochem Biophys Res Commun 1998;245:190-3.


For citation:


Karpenko M.A., Shatskaya E.G., Solntsev V.N., Bogdanov M.A., Larionova V.I. ACUTE CEREBROVASCULAR EVENTS IN PATIENTS WITH ARTERIAL HYPERTENSION: MOLECULAR GENETIC ASPECTS. Rational Pharmacotherapy in Cardiology. 2008;4(1):33-38. (In Russ.) https://doi.org/10.20996/1819-6446-2008-4-1-33-38

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