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ATRIAL FIBROSIS IS A MORPHOLOGICAL BASIS OF ATRIAL FIBRILLATION

https://doi.org/10.20996/1819-6446-2013-9-4-417-419

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Abstract

Mechanisms of atrial fibrosis including the role of serotonin in the development of this lesion in patients with atrial fibrillation are presented. New approaches to the treatment of atrial fibrillation aimed at atrial fibrosis reduction are discussed.

About the Authors

O. M. Drapkina
I.M. Sechenov First Moscow State Medical University, Moscow
Russian Federation


A. V. Emelyanov
I.M. Sechenov First Moscow State Medical University, Moscow
Russian Federation


References

1. Savelieva I, Camm J. Update on atrial fibrillation: part I. Clin Cardiol 2008; 31: 55-62.

2. Burstein B, Nattel S. Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation. J Am Coll Cardiol 2008; 51:802-9.

3. Everett TH, Olgin JE. Atrial fibrosis and the mechanisms of atrial fibrillation. Heart Rhythm 2007; 4: S24-27.

4. Frustaci A, Chimenti C, Bellocci F, et al. Histological substrate of atrial biopsies in patients with lone atrial fibrillation. Circulation 1997; 96:1180-4.

5. Tseluyko B. J., Dmitriev SY The role of interstitial fibrosis as a predictor of atrial fibrillation. Medical Emer- gency conditions in 2007, 3 (10): 124-6. Russian (Целуйко В. Й., Дмитриев С.Ю. Роль интерсти- циального фиброза как предиктора возникновения фибрилляции предсердий. Медицина Неотложных Состояний 2007; 3(10): 124-6).

6. Schotten U., Verheule S., Kirchhof P., Goette A. Pathophisiological mechanisms of atrial fibrillation – a translational appraisal. Physiol Rev 2011;91(1):265-325.

7. Daoud E.G., Bogun F., Goyal R., et al. Effect of atrial fibrillation on atrial refractoriness in humans. Circulation 1996; 94: 1600-1606.

8. Drapkina OM. RAAS and fibrosis. Hepato-cardiac relationship. Russian Journal of Medicine, 2011; 18: 1136-9. Russian (Драпкина О.М. РААС и фиброз. Гепатокардиальные связи. Русский Медицинский Журнал 2011; 18: 1136-9).

9. Сipollone F., Fazia M., Mincione G., et al. Increased expression of transforming growth factor-beta1 as a stabilizing factor in human atherosclerotic plaques. Stroke 2004; 35: 2253-7.

10. Frustaci A., Chimenti C., Bellocci F., et al. Histological substrate of atrial biopsies in patients with lone atrial fibrillation. Circulation 1997; 96: 1180-4.

11. Pacala R., Benedict C.R. Effect of serotonin and tromboxane A2 on endothelial cell proliferation: effect of specific receptor antagonist. J Lab Clin Med 1998;131:527-37.

12. Pacala R., Willerson J.T., Benedict C.R. Effect of serotonin, tromboxane A2 and specific antagonist on vascular smooth muscle cell proliferation. Circulation 1997;96:2280-6.

13. Nigmatullina RR, Mirolyubov LM, Mustafin AA. Serotonergic system in the pathogenesis of formation of pulmonary arterial hypertension in children with congenital heart defects. Kazan Medical Journal 2009; (3): 309-13. Russian (Нигматуллина Р.Р., Миролюбов Л.М., Мустафин А.А. Серотонинергическая система в патогенезе формирования легочной артериальной гипертензии у детей с врожденными пороками сердца. Казанский Медицинский Журнал 2009; (3): 309-13).


Review

For citations:


Drapkina O.M., Emelyanov A.V. ATRIAL FIBROSIS IS A MORPHOLOGICAL BASIS OF ATRIAL FIBRILLATION. Rational Pharmacotherapy in Cardiology. 2013;9(4):417-419. (In Russ.) https://doi.org/10.20996/1819-6446-2013-9-4-417-419

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ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)