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According to WHO data, arterial hypertension (HT) is revealed in 15-20% of pregnant women. In different regions of Russia the incidence of pregnancy HT varies from 7 to 29%. In women with HT started before pregnancy , perinatal losses are observed in 3, 8%, premature births – in 15, 3% and intrauterine growth retardation - in 16, 6%. Physiological gestational changes of hemodynamics are described. Hypertensive pregnant patients of high and low risk are defined. Non-pharmacological treatment of pregnant women with HT is presented in details. Antihypertensive therapy may not be used in hypertensive patients of low risk with blood pressure (BP) of 140-160\90-110 mm Hg. If BP is higher antihypertensive therapy should be used immediately. Dihydropyridine calcium antagonists (CA) is drugs of choice for HT treatment during pregnancy , especially “advanced” CA of the third generation. They have predictable efficacy. It is possible to use short-acting nifedipine for treatment of acute HT in pregnant patients.

About the Author

R. I. Striuk
Moscow state medico-stomatological University
Russian Federation


1. Шехтман М.М., Бурдули Г .М. Болезни органов дыхания и кровообращения у беременных. М.: Триада-Х, 2002: 232.

2. Lenfant C. Гипертензия и ее последствия: состояние проблемы в мире. Артериальная гипертензия. 2005; 2: 86-90.

3. Ариас Ф. Беременность и роды высокого риска. Перевод с англ. М., Медицина. 1989: 654.

4. Mone S.M., Sanders S.P ., Colan S.D. Control Mechanisms for Physiological Hypertrophy of Pregnancy. Circulation. 1996; 94: 667-672.

5. Минкин Р .И. Состояние гемодинамики у беременных с артериальной гипертензией и ее коррекция. Автореф. дис…к.м.н. Уфа, Башкирский мед. институт МЗ РФ. 1993: 24.

6. SpaandermanM.E.A.,MeertensM., van BusselM. et al. Cardiac output increases independently of basal metabolic rate in early human pregnancy. Am.J.Physiol.Heart Circ. Physiol. 2000; 167(5): 1585- 1588.

7. Simmons L.A., Gillin A.G., Jeremy R.W. Structural and functional changes in left ventricle during normotensive and preeclamptic pregnancy. Am.J.Physiol.Heart Circ. Physiol. 2002; 283(4): 1627-1633.

8. Guadelines Committee. 2003 European Society of Hypertension – European Society of Cardiology guidelines for the management of arterial hypertension. J.Hypertension. 2003; 21(6): 1011-1053.

9. Poppas A., Shroff S.G., Korcarz C.E. et al. Serial Assessment of the Cardiovascular System in Normal Pregnancy. Role of Arterial Compliance and Pulsatile Arterial Load. Circulation. 1997; 95: 2407- 2415.

10. Зозуля О.В. Течение гипертонической болезни у беременных. Механизмы развития, ранняя диагностика и профилактика осложнений: Автореф. дис. д.м.н. М., ММА им. И.М. Сеченова. 1997: 45.

11. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk by Gerald G. Briggs, Roger K. Freeman, and Summer J. Yaffe. Phyladelphia, Lippincott Williams and Wilkins, 2005:1858.

12. Opie L.H. Calcium antagonists and the acutely ischemic heart. Engl. art. 1983; Suppl C: 93-100.

13. Furberg C.D., Psaty B.M., Meyer I.V. Nifedipine. Dose-related increase in mortality in patients with coronary heart disease. Circulation. 1995; 92: 1326-1331.

14. Magee L.A., Schick B., Donnenfeld A.E. et al. The safety of calcium channel blockers in human pregnancy: a prospective, multicenter cohort study. Am. J. Obstet. Gynecol. 1996; 174: 823-828.

15. Magee L.A., Koren G. The use of teratogen information services for research6 assessment of reliability of data entry. Reprod. Toxicol.- 1994; 8: 419-424.

16. Bortolus R., Ricci E., Chatenoud L., Parazzini F . Nifedipini administered in pregnancy: effect on the development of children at 18 months. BJOG. 2000; 107(6): 792-794.

17. Давидович И.М., Блощинская И.А., Петричко Т .А. Артериальная гипертония и беременность: механизмы формирования, эффективность амлодипина (Нормодипин). РМЖ 2003; 4: 197-200.

For citation:

Striuk R.I. CALCIUM ANTAGONISTS IN THE TREATMENT OF ARTERIAL HYPERTENSION DURING PREGNANCY. Rational Pharmacotherapy in Cardiology. 2006;2(4):53-57. (In Russ.)

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