Preview

Rational Pharmacotherapy in Cardiology

Advanced search

REPORT ON OPEN MULTICENTRAL RESEARCH PROGRAM “PRIORITY” IN CLINICAL PRACTICE. (PEKTROL – QUALITY OF LIFE IN PATIENTS WITH STABLE ANGINA PECTORIS TREATED WITH ISOSORBIDE-5-MONONITRATE IN LONG-ACTING PRESENTATION)

https://doi.org/10.20996/1819-6446-2006-2-4-25-29

Full Text:

Abstract

Aim. In multicentral program PRIORITY to estimate the efficacy of antianginal therapy after switching patients with stable angina from therapy with short-acting nitrates or isosorbide dinitrate in long-term acting formulation to therapy with isosorbide-5-mononitrate (Pectrol, KRKA, Slovenia) in once daily administrated presentation. Materials and methods. PRIORITY program was held in out-patient clinics of 14 cities. 286 patients with stable angina, who took short-acting nitrates or isosorbide dinitrate in long-term acting formulation, were included in research. Patients were switched without any break to the therapy with isosorbide-5-mononitrate (ISMN) in doze of 40 mg once a day , concomitant therapy was not changed. Initially and after 3 months of treatment with ISMN angina functional class, current therapy with nitrates and concomitant therapy were defined. Quality of life was also determined by questionnaire. Results. 275 patients finished programand 261 of themwere completely corresponded to the study protocol. The treatment with ISMN reduced the frequency and duration of angina attacks (p<0,001), the frequency of sublingual nitroglycerine intake, resulted in the reduction of functional class of angina (p<0, 0001), the increase in walk distance without chest pain or dyspnoea (p<0, 0001). According to questioning 3 months treatment with ISMN resulted in physical exercise tolerance increase (p<0, 0001), reduction in number of side-effects of nitrates therapy (p<0, 0001) and frequency of angina attacks (p<0, 0001). Intensity of psychological discomfort was reduced (p<0,0001) and satisfaction with therapy was increased (p<0, 0001). Conclusion. Switching from short-acting nitrates or isosorbide dinitrate in long-term acting formulation to the therapy with ISMN showed corrective influence on life quality in patients with stable angina: frequency and duration of angina attacks significantly reduced, physical exercise tolerance increased, psycho-emotional condition and patient compliance improved.

About the Author

Yu. A. Karpov
Russian cardiological research and production complex of Roszdrav
Russian Federation


References

1. Диагностика и лечение стабильной стенокардии. Российские рекомендации. Подготовлен комитетом экспертов ВНОК, секция ИБС

2. ACC/AHA/ACP-ASIM Guidelines for the management of patients with chronic stable angina. Circulation 1999;99:2829-48

3. Prevention of coronary heart disease in clinical practice. Recommendations of the Second Joint Task Force of European and other Societies on coronary prevention. Eur Heart J 1998;19:1434- 503.

4. Jaffrani N.A., Ehrenpreis S., Laddu A., Somberg J. Therapeutic approach to unstable angina- nitroglycerin, heparin and combined therapy. Am. Heart J. 1993; 126; 5: 1239-1242.

5. Taylor S.H. Drug therapy and quality of life in angina pectoris. Am. Heart J. 1987; 114: 234-240.

6. Zwinderman A.H., Niemeyer M.G. and others Application of item responsemodeling for quality of life assessment: effects of two nitrate treatment regiments in stable angina pectoris. Proceedings of Symposium 10 2nd Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT) Berlin, September 17-20, 1997; 48-56.

7. Reeves J.T. Medical management of the patient with angina pectoris: on overview of the problem. Circulation. 1982; II; 56: 3-12.

8. Ignarro L.J., Byms R.E., Buga G.M., Wood K.S. Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical. Cire Res. 1987; 61: 866-879.

9. Furchgott R.F ., Zawadzki J.V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980; 288: 373-376.

10. Myers P .R., Minor R.L. Jr ., Guerra R. Jr ., Bates J.N., Harrison D.G. Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide. Nature. 1990; 345: 161-163.

11. Parker J.O., Wisenberg G. Antianginal effects of sustained release isosorbide-5-mononitrate. Circulacion. 1989; П; 80: 267-268.

12. Сидоренко Б.А., Преображенский Д.В. Место мононитратов в терапии ишемической болезни сердца. Кардиология. 2000; 7: 85-96.


For citation:


Karpov Yu.A. REPORT ON OPEN MULTICENTRAL RESEARCH PROGRAM “PRIORITY” IN CLINICAL PRACTICE. (PEKTROL – QUALITY OF LIFE IN PATIENTS WITH STABLE ANGINA PECTORIS TREATED WITH ISOSORBIDE-5-MONONITRATE IN LONG-ACTING PRESENTATION). Rational Pharmacotherapy in Cardiology. 2006;2(4):25-29. (In Russ.) https://doi.org/10.20996/1819-6446-2006-2-4-25-29

Views: 296


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)