Preview

Rational Pharmacotherapy in Cardiology

Advanced search

ANGIOTENSIN CONVERTING ENZYME INHIBITORS: DECREASE IN HEART REMODELING AND IMPROVEMENT IN FUNCTION OF ENDOTHELIUM IN PATIENTS WITH ARTERIAL HYPERTENSION

https://doi.org/10.20996/1819-6446-2006-2-4-12-17

Full Text:

Abstract

Aim. To estimate an effect of enalapril, angiotensin converting enzyme (ACE) inhibitor , on left ventricular hypertrophy and endothelium function in patients with arterial hypertension (HT). Material and methods. 41 patients with HT of I-III grade were included into the study. A part of patients received enalapril in an average daily doze of 10 mg. Parameters of microcirculatory reactivity and computer electrocardiogram analysis according to original technique were studied. Results. Microcirculatory indices showed that 6 month enalapril treatment resulted in significant improvement of disturbed function of vascular endothelium. Reduction of left ventricular hypertrophy also was demonstrated. Conclusion. ACE inhibitors should be widely recommended in hypertensive patients due to their vascular and heart remodeling positive effects.

About the Authors

K. Yu. Nikolaev

Russian Federation


G. I. Lifshits

Russian Federation


A. A. Nikolaeva

Russian Federation


I. M. Gicheva

Russian Federation


References

1. The ALLHAT Officers and Coordinators. Major outcomes in high-risk hypertensive patients randomized to ACE inhibitor or calciumchannel blocker vs diuretic (ALLHAT). JAMA. 2002;288:2981-2997.

2. Шальнова С.А. Оценка и управление суммарным риском сердечно-сосудистых заболеваний у населения России. С.А. Шальнова, Р .Г . Оганов, А.Д. Деев. Кардиоваскуляр. терапия и профилактика, 2004;4:4-11.

3. Dzau V., Bernstein K., Celermaier D. et al. The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data. Am J Cardiol 2001;88:Suppl L:1-20.

4. Николаев К.Ю., Пархоменко Е.И., Лифшиц Г .И. и др. Воспроизводимость показателей эндотелий-зависимой сосудистой реактивности микроциркуляторного русла. Омский научный вестник.- 2005;1:198-200.

5. Останькович А.А., Кузнецов А.А., Лапицкая И.В. и др. Детекция гипертрофии левого желудочка по диаграмме информационного состояния на компьютерной ЭКГ . Патология кровообращения и кардиохирургия, 2003;2:67-72.

6. Кобалава Ж.Д., Склизкова Л.А., КотовскаяЮ.В., и др.Представления об артериальной гипертонии у пожилых и реальная клиническая практика в России (результаты I этапа российской научно-практической программы АРГУС). Кардиология, 2001;7:11-14.

7. Taddei S., Virdis A.,Mattei P . Et al. Vasodilation to acetylcholine in primary and secondary forms of hypertension. Hypertension. 1993;21:929–933

8. Rizzoni D., Porteri E., Castellano M. et al. Endothelial dysfunction in hypertension is independent from the etiology and from vascular structure. Hypertension. 1998;31 (pt 2):335–341.

9. Vanhoutte PM., Boulanger CM. Endothelium–dependent responses in hypertension. Hypertens Res 1995 Jun;18(2):87–98

10. Panza JA. Endothelial dysfunction in essential hypertension. Clin Cardiol 1997 Nov;20(11 Suppl 2):II–26–33

11. Scholkens B.A., Unger T. ACE Inhibitors, Endothelial function and Atherosclerosis. Amsterdam Media Medica Publications. March 1993

12. Bonner G., Preis S., Schunck U et al. Hemodynamic effects of bradykinin on systemic and pulmonary circulation in healthy and hypertensive humans. J Cardiovasc Pharmacol 1990;15 (suppl 6): 46–56.

13. Griendling K.K., Minieri C.A., Ollerenshaw J.D. et al. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ. Res.1994;74:1141–1148

14. Mancini GBJ., Henry Gc., Macaya C., et al. Angiotensin–converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease: the TREND (Trial on Reversing Endothelial Dysfunction) Study. Circulation.1996; 94:258–265.


For citation:


Nikolaev K.Y., Lifshits G.I., Nikolaeva A.A., Gicheva I.M. ANGIOTENSIN CONVERTING ENZYME INHIBITORS: DECREASE IN HEART REMODELING AND IMPROVEMENT IN FUNCTION OF ENDOTHELIUM IN PATIENTS WITH ARTERIAL HYPERTENSION. Rational Pharmacotherapy in Cardiology. 2006;2(4):12-17. (In Russ.) https://doi.org/10.20996/1819-6446-2006-2-4-12-17

Views: 326


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)