Rational Pharmacotherapy in Cardiology

Advanced search


Full Text:


Alcohol abuse and particularly extension of alcohol consumption in alcohol diseas increases the risk of cardiac arrhythmias development and aggravates existing arrhythmias. Patients do not always receive the necessary specific treatment due to lack of detection of the ethanol genesis of these arrhythmias. Management of patients with alcohol abuse and alcohol dependence, including its cardiac complications among other cardiac arrhythmias should use both antiarrhythmic and anti-alcohol drugs and antidepressants. Such issues as diagnosis and management of patients with alcohol-induced cardiac arrhythmias are presented.

About the Authors

A. O. Yusupova
I.M. Sechenov First Moscow State Medical University
Russian Federation
Trubetskaya ul., 8-2, Moscow, 119991 Russia

A. S. Lishuta
I.M. Sechenov First Moscow State Medical University
Russian Federation
Trubetskaya ul., 8-2, Moscow, 119991 Russia


1. Nutrition and your health: dietary guidelines for Americans. 4th ed. Home and Garden Bulletin. Washington DC: U.S. Department of Health and Human Services, Department of Agriculture (USDA); 1995

2. World Health Organization. Manage¬ment of Substance Abuse Team. Global status report on alcohol and health. Ge¬neva, Switzerland: World Health Organi¬zation; 2011

3. 2013 National Survey on Drug Use and Health (NSDUH). Table 2.46B—Alcohol Use, Binge Alcohol Use, and Heavy Alcohol Use in the Past Month among Persons Aged 18 or Older, by Demographic Characteristics: Percentages, 2012 and 2013. Available at:

4. files/NSDUH-DetTabsPDFWHTML2013/Web/HTML/NSDUH-DetTabsSect2peTabs43to84-2013.htm#tab2.46b. Accessed by 01.06.2015

5. Centers for Disease Control and Prevention. Alcohol use and health. Available at: Accessed by 01.06.2015.

6. Schorling JB, Buchsbaum DG. Screening for alcohol and drug abuse. Med Clin North Am 1997;81:845-65

7. Popova S, Rehm J, Patra J. Comparing alcohol consumption in central and eastern Europe to other European countries. Alcohol and Alcoholism 2007;42 (5):465-73

8. Anderson P, Baumberg B, eds. Alcohol in Europe: a public health persepctive. A report for the European Commission. Luxembourg: European Communities; 2006

9. Leon DA, Chenet L, Shkolnikov VM, et al. Huge variation in Russian mortality rates 1984-94: artefact, alcohol, or what? Lancet 1997; 350(9075): 383-8.

10. Iluk RD, Rybakova KV, Kiselev AS et al. Epidemiology and medico-social characteristics depending on beer and spirits. Zhurnal Nevrologii i Psikhiatrii 2011; (11): 3-13. Russian (Илюк Р. Д., Рыбакова К. В., Киселёв А. С. и др. Эпидемиология и медико-социальные особенности зависимости от пива и крепких алкогольных напитков. Журнал Неврологии Психиатрии 2011;(11): 3-13

11. Health care in Russia, in 2013. Statistical collection. Moscow: Rosstat; 2013. Russian (Здравоохранение в России, 2013. Статистический сборник. Москва: Росстат; 2013)

12. Koshkina EA, Kirzhanova VV, Guseva OI, et al. Providing drug treatment population of the Russian Federation in 2012. Voprosy Narkologii 2013; (4): 3-18. Russian (Кошкина Е.А., Киржанова В.В., Гусева О.И. и др. Оказание наркологической помощи населению российской федерации в 2012 г. Вопросы Наркологии 2013; (4): 3-18)

13. Koshkina EA, Kirzhanova VV, Guseva OI, Miroshnikova YV. Main indicators of substance abuse services in the Russian Federation in 2012-2013. Statistical Yearbook. Moscow: Russian Ministry of Health, National Scientific Center on Addiction: 2014. Russian (Кошкина Е.А., Киржанова В.В., Гусева О.И., Мирошникова Ю.В. Основные показатели деятельности наркологической службы в Российской Федерации в 2012-2013 годах. Статистический сборник. Москва: МЗ РФ, ФГБУ «Национальный научный центр наркологии»: 2014)

14. Centers for Disease Control and Prevention. Excessive drinking costs U.S. $223.5 billion. Available at: Accessedby 01.06.2015

15. Patel V.C., Why H.J., Richardson P.J.,Preedy V.R. The effects of alcohol on the heart. Adverse Drug React Toxicol Rev 1997; 16: 15-43.

16. Hookana E, Junttila MJ, Puurunen VP, et al. Causes of non ischemic sudden cardiac death in the current era. Heart rhythm: the official journal of the Heart Rhythm Society 2011;8:1570-5

17. Horton J.W., White J.D. Cardiac contractile and sarcoplasmic reticulum function after acute ethanol consumption. J Surg Res 1996; 64: 132-8.

18. Vary T.C., Deiter G., Goodman A.S. Acute alcohol intoxication enhances myocardial eIF4G phosphorylation despite reducing mTOR signaling. Am J Physiol Heart Circ Physiol 2005; 288: H121-128

19. Atkinson L., Why H., Ward R.J. et al. Antioxidant status in dilated cardiomyopathy and alcohol heart muscle disease. Alcohol and Alcoholism 1992; 28: 67-73

20. Gajewski J., Singer R.B. Mortality in an insured population with atrial fibrillation. JAMA 1981; 245: 1540–4

21. Abusaada K., Sharma S.B., Jaladi R., Ezekowitz M.D. Epidemiology and management of new-onset atrial fibrillation. Am J Manag Care 2004; 10: S50-57.

22. Frost L., Vestergaard P. Alcohol and risk of atrial fibrillation or flutter–a cohort study. Arch Intern Med 2004; 164: 1993-8

23. Overvad TF, Rasmussen LH, Skjøth F. Alcohol intake and prognosis of atrial fibrillation. Heart 2013;99(15):1093-9

24. Djousse L., Levy D., BenjaminE.J., et al. Long-term alcohol consumption and the risk of atrial fibrillation in the Framingham study. Am J Cardiol 2004; 93: 710-3

25. Mukamal K.J., Tolstrup J.S., FribergJ., et al. Alcohol consumption and risk of atrial fibrillation in men and women - the Copenhagen City Heart Study. Circulation 2005; 112: 1736-42

26. Mukamal K.J., Psaty B.M., Rautaharju P.M., et al. Alcohol consumption and risk and prognosis of atrial fibrillation among older adults: the Cardiovascular Health Study. Am Heart J 2007; 153: 260-6

27. Guize L., Thomas F., Bean K., et al. Fibrillation atriale: prevalence, facteurs de risqué et mortalitédansunevaste population françaisesuivie 15 ans. Bull Acad Natl Med 2007; 191: 791-803

28. Lee SH. Risk factors between patients with lone and non-lone atrial fibrillation. J Korean Med Sci2013;28(8):1174-80

29. Larsson SC, Drca N, Wolk A. Alcohol consumption and risk of atrial fibrillation: a prospective study and dose-response meta-analysis. J Am Coll Cardiol 2014;64(3):281-9

30. Kupari M., Koskinen P. Alcohol, cardiac arrhythmias and sudden death. Novartis Found Symp 1998; 216: 68–79

31. George A, Figueredo VM. Alcohol and arrhythmias: a comprehensive review. J Cardiovas Med 2010;11(4):221-8

32. Axelrod AS, Sirkin AL. Alcohol-induced cardiac arrhythmias in patients with alcohol dependence: options for arrhythmias, the mechanisms of their origin, the course and antiarrhythmic therapy. Ration Pharmacother Cardiol 2015; 11 (2): 124-31. Russian (Аксельрод А.С., Сыркин А.Л. Алкогольиндуцированные нарушения сердечного ритма у пациентов с алкогольной зависимостью: варианты аритмий, механизмы их возникновения, особенности течения и антиаритмической терапии. Рациональная фармакотерапия в кардиологии 2015;11(2):124-31)

33. Marcus G.M., Smith L.M., Whiteman D., et al. Alcohol intake is significantly associated with atrial flutter in patients under 60 years of age and a shorter right atrial effective refractory period. Pacing Clin Electrophysiol 2008; 31: 266–72.

34. Benjamin E.J., Levy D., Vaziri S.M., et al. Independent risk factors for atrial fibrillation in a populationbased cohort: The Framingham Heart Study. JAMA 1994; 271: 840–4.

35. Hémery Y., Broustet H., Guiraudet O., et al. Alcohol and rhythm disorders. Ann Cardiol Angeiol (Paris) 2000; 49(8): 473–9

36. Cuculi F, Kobza R, Ehmann T, Erne P. ECG changes amongst patients with alcohol withdrawal seizures and de¬lirium tremens. Swiss Med Wkly 2006;136(13–14):223–7.

37. Otero-Antón E, González-Quintela A, Saborido J, et al. Prolongation of the QTc interval during alcohol withdrawal syndrome. ActaCardiol1997;52(3):285–94

38. Nemtsov AV, Terekhin AT. Dimensions and diagnostic composition of alcoholic mortality in Russia. Narkologiia 2007; 12: 4-7. Russian (Немцов А.В., Терехин А.Т. Размеры и диагностический состав алкогольной смертности в России. Наркология 2007; 12: 4-7)

39. Albert CM, Manson JE, Cook NR, et al. Moderate alcohol consumption and the risk of sudden cardiac death among US male physicians. Circulation 1999;100(9):944–50

40. Chiuve SE, Rimm EB, Mukamal KJ, et al. Light-to-moderate alcohol consumption and risk of sudden cardiac death in women. Heart Rhythm 2010;7(10):1374–80

41. Day CP, James OF, Butler TJ, Campbell RW. QT prolongation and sudden cardiac death in patients with alcoholic liver disease. Lancet 1993;341(8858):1423–8

42. Akamatsu Y, Hayashi T, Sakane N, Moritani T. Effect of aldehyde dehydro¬genase-2 genotype on cardiac autonomic nervous responses to moderate alcohol ingestion. Alcohol Clin Exp Res 2008;32(8):1422–8

43. Williams E.S., Mirro M.J., Bailey J.C. Electrophysiological effects of ethanol, acetaldehyde, and acetate on cardiac tissues from dog and guinea pig. Circ Res 1980; 47: 473-48

44. Habuchi Y., Furukawa T., Tanaka H., et al. Ethanol inhibition of Ca2+ and Na+ currents in the guineapig heart. Eur J Pharmacol 1995; 292: 143-19

45. Anadon M.J., Almendral J., González P., et al. Alcohol concentration determines the type of atrial arrhythmia induced in a porcine model of acute alcoholic intoxication. Pacing Clin Electrophysiol 1996; 19: 1962-7

46. Fenelon G., Balbao C.E.B., Fernandes R., et al. Characterization of the acute cardiac electrophysiologic effects of ethanol in dogs. Alcohol Clin Exp Res 2007; 31: 1574-80

47. Wong M. Depression of cardiac performance by ethanol unmasked during autonomic blockade. Am Heart J 1973; 86: 508-15.

48. Rosenqvist M. Alcohol and cardiac arrhythmias. Alcohol Clin Exp Res 1998; 22: 318S-322S 58

49. Nutt D.J., Liam N.J. Addiction. Oxford: Oxford University Press; 2013

50. WHO. Global status report on alcohol and health 2014. Avaiable at: Accessed by 01.06.2015.

51. Rehm J, Zatonksi W, Taylor B, Anderson P. Epidemiology and alcohol policy in Europe. Addiction 2011;106(Suppl 1):11–9.

52. Friedmann PD. Clinical practice. Alcohol use in adults. N Engl J Med 2013;368(4):365-73.

53. Bush K, Kivlahan DR, McDonell MB, et al. The AUDIT alcohol consumption questions (AUDIT-C): an effective brief screening test for problem drinking. Ambulatory Care Quality Improvement Project (ACQUIP). Alcohol Use Disorders Identification Test. Arch Intern Med 1998;158(16):1789-95

54. Mayfield D, McLeod G, Hall P. The CAGE questionnaire: validation of a new alcoholism instrument. Am J Psychiatry 1974; 131: 1121-3.

55. Ewing JA. Detecting alcoholism, the CAGE questionnaire. JAMA 1984; 252: 1905-7

56. Sinha R, Fox HC, Hong KA, et al. Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals. Neuropsychopharmacology 2009;34(5):1198-208

57. Kushner MG, Abrams K, Thuras P, et al. Follow-up study of anxiety disorder and alcohol dependence in comorbid alcoholism treatment patients. Alcohol Clin Exp Res 2005;29:1432–43 71

58. Boden JM, Fergusson DM. Alcohol and depression. Addiction 2011;106(5):906-14

59. Kessler RC, McGonagle KA, Zhao S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry. 1994;51(1):8-19

60. Schuckit M. A., Kelsoe J. R., Braff D. L., Wilhelmsen K. C. Some possible genetic parallels across alcoholism, bipolar disorder and schizophrenia. Journal of Studies on Alcohol 2003; 64: 157–9

61. Watkins LL, Blumenthal JA, Davidson JR, et al. Phobic anxiety, depression, and risk of ventricular arrhythmias in patients with coronary heart disease. Psychosom Med 2006;68(5):651-6.

62. Vlastelica M. Emotional stress as a trigger in sudden cardiac death. Psychiatr Danub 2008;20(3): 411-4.

63. Pompili M, Serafini G., Innamorati M., et al. Suicidal Behavior and Alcohol Abuse. Int J Environ Res Public Health 2010; 7: 1392-431

64. Beck A, Steer R. Beck depression inventory: Manual. USA: Harcourt, Brace, Jovanovich; 1987.

65. Beck A, Steer R. Beck anxiety inventory: Manual. USA: Harcourt, Brace Jovanovich; 1990.

66. McPherson A, Martin CR. Is the Hospital Anxiety and Depression Scale (HADS) an appropriate screening tool for use in an alcohol-dependent population? J Clin Nurs 2011;20(11-12):1507-17 78

67. Asimova YE. Anxious-depressive disorders in alcoholism. Meditsinskiy Sovet 2014; (10): 64-9. Russian (Азимова Ю.Э. Тревожно-депрессивные нарушения при алкоголизме. Медицинский Совет 2014; (10): 64-9)

68. Heather N, Adamson SJ, Raistrick D, et al. Initial preference for drinking goal in the treatment of alcohol problems: I. Baseline differences between abstinence and non-abstinence groups. Alcohol and Alcoholism 2010;45(2):128–35.

69. Hodgins DC, Leigh G, Milne R, Gerrish R. Drinking goal selection in behavioral self-management treatment of chronic alcoholics. Addict Behav 1997;22(2):247–255

70. Orford J, Keddie A. Abstinence or controlled drinking in clinical practice: a test of the dependence and persuasion hypotheses. Br J Addict 1986;81(4):495–504

71. EMEA (2010): Guideline on the development of medicinal products for the treatment of alcohol dependence. EMEA/CHMP/EWP/20097/2008. Available at: Accessed by 01/06.2015

72. van den Brink W, Aubin HJ, Bladström A, et al. Efficacy of as-needed nalmefene in alcohol-dependent patients with at least a high drinking risk level: results from a subgroup analysis of two randomized controlled 6-month studies. Alcohol and Alcoholism 2013; 48(5): 570-8

For citation:

Yusupova A.O., Lishuta A.S. ALCOHOL AND HEART RHYTHM DISORDERS. Rational Pharmacotherapy in Cardiology. 2015;11(3):317-326. (In Russ.)

Views: 593

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)