Polymetabolic disorders after hysterectomy: a chance or a rule?

V.I. Podzolkov1, T.I. Nikitina2, A.E. Bragina1*, N.M. Podzolkova2

1 I.M. Sechenov First Moscow State Medical University

2 Russian Medical Academy of Post-Diploma Education, Moscow, Russia

Aim. To study the dynamic of metabolic disorders in patients after hysterectomy with intact ovaries.

Material and methods. 104 women (aged 44.0±2.1) after hysterectomy with intact ovaries were examined. All patients were split into three subgroups according to time after hysterectomy (1, 3, and 5 years). 25 women (aged 43.0±1.6) with normal menstrual function were included into the control group. Blood pressure (BP) levels and body mass index were measured. Serum lipids profile, plasma levels of immune-reactive insulin (IRI) and C-peptide were investigated in fasting condition and after oral glucose tolerance test.

Results. Increase in time after hysterectomy was associated with significant elevation of body mass index, systolic and diastolic BP, basal and stimulated IRI and C-peptide levels, as well as serum levels of total cholesterol and low density lipoprotein cholesterol. These parameters had significant positive correlations with time after hysterectomy.

Conclusion. Polymetabolic disorders were more prominent in patients with longer time after hysterectomy. These findings can be basis for definition of post-hysterectomy metabolic syndrome stages.

Key words: post-hysterectomy syndrome, metabolic syndrome.

Rational Pharmacother. Card. 2011;7(3):294-299

* Corresponding author: anna.bragina@mail.ru

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